{{Rsnum
|rsid=2227631
|Gene=SERPINE1
|Chromosome=7
|position=101126257
|Orientation=plus
|GMAF=0.4408
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SERPINE1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 23.9 | 63.7 | 12.4
| HCB | 16.3 | 47.4 | 36.3
| JPT | 15.0 | 57.5 | 27.4
| YRI | 2.7 | 36.1 | 61.2
| ASW | 5.3 | 47.4 | 47.4
| CHB | 16.3 | 47.4 | 36.3
| CHD | 16.7 | 41.7 | 41.7
| GIH | 21.8 | 54.5 | 23.8
| LWK | 3.7 | 30.3 | 66.1
| MEX | 13.8 | 46.6 | 39.7
| MKK | 17.9 | 51.9 | 30.1
| TSI | 44.6 | 37.6 | 17.8
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2227631
|Name_s=
|Gene_s=SERPINE1
|Feature=
|Evidence=PubMed ID:18794724
|Annotation=This variant was shown to be assoicated with antidepressant treatment response in a study consisting of 188 Chinese MDD patients and 346 controls.The G allele was less frequent in responders than nonresponders
|Drugs=citalopram; fluoxetine
|Drug Classes=
|Diseases=Depression; Depressive Disorder, Major
|Curation Level=Curated
|PharmGKB Accession ID=PA162370402
}}

{{PMID Auto
|PMID=21752301
|Title=Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head
|OA=1
}}

{{PMID Auto
|PMID=22133274
|Title=Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection
|OA=1
}}

{{PMID Auto
|PMID=16172282
|Title=Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels.
}}

{{PMID Auto
|PMID=16424345
|Title=Plasminogen activator inhibitor-1 gene: selection of tagging single nucleotide polymorphisms and association with coronary heart disease.
}}

{{PMID Auto
|PMID=17656673
|Title=Association of plasminogen activator inhibitor (PAI)-1 (SERPINE1) SNPs with myocardial infarction, plasma PAI-1, and metabolic parameters: the HIFMECH study.
}}

{{PMID Auto
|PMID=18853133
|Title=Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18974842
|Title=Gender differences in genetic risk profiles for cardiovascular disease.
|OA=1
}}

{{PMID Auto
|PMID=19360663
|Title=Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder.
|OA=1
}}

{{PMID Auto
|PMID=19368854
|Title=No association between the promoter polymorphisms of PAI-1 gene and sporadic Alzheimer's disease in Chinese Han population.
}}

{{PMID Auto
|PMID=19526059
|Title=Polymorphic variation of genes in the fibrinolytic system and the risk of ovarian cancer.
|OA=1
}}

{{PMID Auto
|PMID=22503724
|Title=Promoter polymorphisms of SERPINE1 are associated with the antidepressant response to depression in Alzheimer's disease.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2227631
|overall_frequency_n=70
|overall_frequency_d=126
|overall_frequency=0.555556
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=66
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=22990020
  |Trait=Plasminogen activator inhibitor type 1 levels (PAI-1)
  |Title=Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
  |RiskAllele=
  |Pval=3E-24
  |OR=.07
  |ORtxt=[NR] unit increase
  |OA=1
}}

{{PMID Auto
|PMID=24135164
|Title=Genetic polymorphisms in plasminogen activator inhibitor-1 predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese population
}}

{{PMID Auto
|PMID=24355042
|Title=Association of five common polymorphisms in the plasminogen activator inhibitor-1 gene with primary ovarian insufficiency
}}

{{PMID Auto
|PMID=25231632
|Title=Pai-1 Gene Variants and COC Use Are Associated with Stroke Risk: A Case-Control Study in the Han Chinese Women
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}