{{Rsnum
|rsid=2227902
|Gene=REST
|Chromosome=4
|position=56930934
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=T
|GMAF=0.0753
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=REST
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 87.5 | 12.5 | 0.0
| HCB | 88.1 | 11.9 | 0.0
| JPT | 83.8 | 15.3 | 0.9
| YRI | 85.6 | 13.0 | 1.4
| ASW | 86.0 | 10.5 | 3.5
| CHB | 88.1 | 11.9 | 0.0
| CHD | 90.8 | 6.4 | 2.8
| GIH | 93.1 | 6.9 | 0.0
| LWK | 78.2 | 20.0 | 1.8
| MEX | 91.1 | 8.9 | 0.0
| MKK | 80.1 | 16.7 | 3.2
| TSI | 85.3 | 14.7 | 0.0
| HapMapRevision=28
}}
{{PMID|18518926}} - [[rs2227902]] and [[rs3796530]] were found to be in 100% LD with a [[variable number tandem repeat]] ([[VNTR]]) length variant in the [[REST]] gene in a sample of 746 elderly Caucasians. Minor alleles (T and A, respectively) at both locations associated with the 4-length VNTR, while common alleles associated with the VNTR 5-length repeat. Carriers of the 4-length VNTR homozygous for the [[Rs6265 | Val66]] variant in the BDNF gene performed slightly, but significantly (p = 0.004), better than those without in the general cognitive tests performed in the study. Carriers of the 5-length VNTR and the [[Rs6265 | 66Met]] BDNF variant had significantly lower g (p = 0.01), but the effect was not as great as the individual effect of the 66Met allele.

{{GET Evidence
|gene=REST
|aa_change=Glu692Asp
|aa_change_short=E692D
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2227902
|overall_frequency_n=831
|overall_frequency_d=10758
|overall_frequency=0.0772448
|n_genomes=7
|n_genomes_annotated=0
|n_haplomes=8
|n_articles=0
|n_articles_annotated=0
|nblosum100=-2
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | Illumina Human 1M}}