{{Rsnum
|rsid=2227928
|Gene=ATR
|Chromosome=3
|position=142562770
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.3825
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ATR
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 23.9 | 57.5 | 18.6
| HCB | 32.6 | 41.5 | 25.9
| JPT | 18.8 | 55.4 | 25.9
| YRI | 76.7 | 21.9 | 1.4
| ASW | 61.4 | 29.8 | 8.8
| CHB | 32.6 | 41.5 | 25.9
| CHD | 17.0 | 53.8 | 29.2
| GIH | 15.8 | 58.4 | 25.7
| LWK | 75.0 | 21.3 | 3.7
| MEX | 20.7 | 63.8 | 15.5
| MKK | 67.3 | 28.8 | 3.8
| TSI | 37.3 | 54.9 | 7.8
| HapMapRevision=28
}}
[[rs2227928]], also known as Ex4+340C>T or T211M, is a SNP in the [[ATR]] gene.

Although not significant on it's own, as 1 of 3 SNPs its risk allele ([[rs2227928]](C)) is associated with poorer overall survival for [[pancreatic cancer]] patients being treated with combined gerncitabine radiation therapy. Median overall survival times of 31.0, 16.2, and 10.5 months were calculated for [[pancreatic cancer]] patients carrying < or = 1, 2, and 3 risk alleles from [[rs664143]](C), [[rs2227928]](C), and [[rs521102]](T;T), respectively (P=0.004).
{{PMID|18381943|OA=1
}}

{{Venter SNP
|rsid=2227928
|allele=G
|frequency=0.583
|uid=1103656248638
|type=homozygous_SNP
|hugo=ATR
|ensembl gene=ENSG00000175054
|ensembl transcript=ENST00000350721
|sift=
|disease=Defects in ATR are a cause of Seckel syndrome 1 (SCKL1) (MIM:210600). SCKL1 is a rare autosomal recessive disorder characterized by growth retardation, microcephaly with mental retardation, and a characteristic 'bird-headed' facial appearance.
}}

{{PMID Auto
|PMID=17010193
|Title=Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families.
|OA=1
}}

{{PMID Auto
|PMID=18191955
|Title=Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.
|OA=1
}}

{{PMID Auto
|PMID=18551366
|Title=Genetic variation in DNA repair pathway genes and premenopausal breast cancer risk.
|OA=1
}}

{{GET Evidence
|gene=ATR
|aa_change=Met211Thr
|aa_change_short=M211T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2227928
|overall_frequency_n=7147
|overall_frequency_d=10758
|overall_frequency=0.664343
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=77
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|nblosum100=2
|autoscore=1
|n_web_uneval=3
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}