{{Rsnum
|rsid=2227956
|Gene=HSPA1L
|Chromosome=6
|position=31810495
|Orientation=minus
|GMAF=0.1221
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=HSPA1L
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 5.3 | 37.2 | 57.5
| HCB | 1.5 | 38.0 | 60.6
| JPT | 0.0 | 16.8 | 83.2
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 7.0 | 93.0
| CHB | 1.5 | 38.0 | 60.6
| CHD | 4.6 | 32.1 | 63.3
| GIH | 2.0 | 34.7 | 63.4
| LWK | 0.0 | 10.0 | 90.0
| MEX | 0.0 | 10.3 | 89.7
| MKK | 1.3 | 26.9 | 71.8
| TSI | 1.0 | 18.6 | 80.4
| HapMapRevision=28
}}{{PMID|18813331|OA=1
}} rs2227956 in HSP70-hom, resulted in a significant association with noise-induced [[hearing loss]]

{{PMID Auto
|PMID=19351530
|Title=Genetic interaction of Hsp70 family genes polymorphisms with high-altitude pulmonary edema among Chinese railway constructors at altitudes exceeding 4,000 meters.
}}

{{PharmGKB
|RSID=rs2227956
|Name_s=
|Gene_s=HSPA1L, HSPA1A, LSM2
|Feature=
|Evidence=PubMed ID:16538175
|Annotation=The C allele of this SNP is part of a haplotype that has been associated with protection from hypersensitivity to carbamazepine.
|Drugs=carbamazepine
|Drug Classes=
|Diseases=Drug Hypersensitivity; Epidermal Necrolysis, Toxic; Stevens-Johnson Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162263497
}}

{{omim
|id=613035
|rsnum=2227956
}}

{{PMID Auto
|PMID=16820586
|Title=Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
|OA=1
}}

{{PMID Auto
|PMID=17009593
|Title=Reduced heat shock response in human mononuclear cells during aging and its association with polymorphisms in HSP70 genes.
|OA=1
}}

{{PMID Auto
|PMID=17009596
|Title=Association of hsp70 polymorphisms with risk of noise-induced hearing loss in Chinese automobile workers.
|OA=1
}}

{{PMID Auto
|PMID=18194558
|Title=A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.
|OA=1
}}

{{PMID Auto
|PMID=18299791
|Title=Association analysis of heat shock protein 70 gene polymorphisms in schizophrenia.
}}

{{PMID Auto
|PMID=18551993
|Title=SNP combinations in chromosome-wide genes are associated with bone mineral density in Taiwanese women.
}}

{{PMID Auto
|PMID=19143815
|Title=MHC fine mapping of human type 1 diabetes using the T1DGC data.
|OA=1
}}

{{PMID Auto
|PMID=19439993
|Title=The impact of heat shock protein 70 gene variations on clinical presentation and outcome in schizophrenic inpatients.
}}

{{PMID Auto
|PMID=19582769
|Title=Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders.
}}

{{PMID Auto
|PMID=20012387
|Title=HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility.
|OA=1
}}

{{GET Evidence
|gene=HSPA1L
|aa_change=Thr493Met
|aa_change_short=T493M
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2227956
|overall_frequency_n=9387
|overall_frequency_d=10758
|overall_frequency=0.87256
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=96
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|pph2_score=0.001
|nblosum100=2
|autoscore=1
|webscore=N
|summary_short=Protection from hypersensitivity to carbamazepine.
}}

{{PMID Auto
|PMID=24872649
|Title=Association between heat shock protein 70 gene polymorphisms and clinical outcomes in intensive care unit patients with sepsis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}