{{Rsnum
|rsid=2228043
|Gene=IL6ST
|Chromosome=5
|position=55956103
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=G
|GMAF=0.1552
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=IL6ST
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 78.5 | 20.0 | 1.5
| HCB | 93.3 | 6.7 | 0.0
| JPT | 95.5 | 4.5 | 0.0
| YRI | 46.0 | 44.4 | 9.5
| ASW | 0.0 | 0.0 | 0.0
| CHB | 93.3 | 6.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

{{Venter SNP
|rsid=2228043
|allele=C
|frequency=0.117
|uid=1103654105125
|type=heterozygous_SNP
|hugo=IL6ST
|ensembl gene=ENSG00000134352
|ensembl transcript=ENST00000381298
|sift=TOLERATED
|disease=Isoform 2 is an autoantigen found in rheumatoid arthritis (RA) but it is not specific to patients with RA.
}}

{{PMID Auto
|PMID=17664290
|Title=Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man.
|OA=1
}}

{{GET Evidence
|gene=IL6ST
|aa_change=Leu397Val
|aa_change_short=L397V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2228043
|overall_frequency_n=2009
|overall_frequency_d=10758
|overall_frequency=0.186745
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=25
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23238918
|Title=Genome-wide pathway analysis of a genome-wide association study on multiple sclerosis.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}