{{Rsnum
|rsid=2228314
|Gene=SREBF2
|Chromosome=22
|position=41880738
|Orientation=plus
|GMAF=0.3664
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=SREBF2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 4.6 | 44.6 | 50.8
| HCB | 6.8 | 31.8 | 61.4
| JPT | 9.1 | 56.8 | 34.1
| YRI | 38.1 | 50.8 | 11.1
| ASW | 0.0 | 0.0 | 0.0
| CHB | 6.8 | 31.8 | 61.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=20111910
|Title=Sterol regulatory element-binding transcription factor (SREBF)-2, SREBF cleavage-activating protein (SCAP), and premature coronary artery disease in a Chinese population
}}

{{PMID Auto
|PMID=22662110
|Title=Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis
|OA=1
}}
{{PMID Auto
|PMID=19116028
|Title=Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death.
|OA=1
}}

{{PMID Auto
|PMID=19740467
|Title=Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population.
}}

{{GET Evidence
|gene=SREBF2
|aa_change=Gly595Ala
|aa_change_short=G595A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2228314
|overall_frequency_n=3988
|overall_frequency_d=10758
|overall_frequency=0.370701
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=44
|n_articles=0
|n_articles_annotated=0
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24992162
|Title=Relationship of SREBP-2 rs2228314 G&gt;C Polymorphism with Nonalcoholic Fatty Liver Disease in a Han Chinese Population
}}

{{PMID Auto
|PMID=25005769
|Title=Association Between Single Nucleotide Polymorphisms of Sterol Regulatory Element Binding Protein-2 and Liver X Receptor α Gene and Risk of Polycystic Ovary Syndrome in a Chinese Han Population
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}