{{Rsnum
|rsid=2228479
|Gene=MC1R
|Chromosome=16
|position=89919532
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.09183
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MC1R
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 12.5 | 87.5
| HCB | 0.7 | 42.3 | 56.9
| JPT | 0.0 | 20.5 | 79.5
| YRI | 0.0 | 0.0 | 0.0
| ASW | 0.0 | 3.5 | 96.5
| CHB | 0.7 | 42.3 | 56.9
| CHD | 6.4 | 44.0 | 49.5
| GIH | 0.0 | 6.0 | 94.0
| LWK | 0.0 | 0.9 | 99.1
| MEX | 0.0 | 10.5 | 89.5
| MKK | 0.0 | 0.0 | 0.0
| TSI | 2.0 | 9.8 | 88.2
| HapMapRevision=28
}}

[[rs2228479]], known as Val92Met or V92M, is one of several SNPs in the [[MC1R]] gene commonly associated with red (or blond) hair and poor tanning, but note its high presence in one Asian population [PMID 7581459, PMID 16463023]

The risk allele is [[rs2228479]](A), compared with the wild-type [[rs2228479]](G) allele.  

See also [http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=155555&a=155555_AllelicVariant0002 OMIM 155555.0002]

{{ neighbor
| rsid = 1805007
| distance = 177
}}
{{ neighbor
| rsid = 1805006
| distance = 22
}}

{{omim
|id=155555
|rsnum=2228479
|variant=0002
}}

{{ClinVar
|rsid=2228479
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=89985940
|CHROM=16
|GMAF=0.0916
|dbSNPBuildID=98
|SSR=0
|SAO=1
|VP=0x050168000000150517110100
|GENEINFO=MC1R:4157
|GENE_NAME=MC1R
|GENE_ID=4157
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000016.9:g.89985940G>A
|CLNORIGIN=1
|CLNSIG=5
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9082; 0.09183
|CLNACC=RCV000015378.24; RCV000015379.24
|CLNDBN=Skin/hair/eye pigmentation 2, red hair/fair skin; Skin/hair/eye pigmentation 2, blond hair/fair skin
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=155555.0002
|COMMON=1
|Disease=Skin/hair/eye pigmentation 2; Skin/hair/eye pigmentation 2
}}

{{PMID Auto
|PMID=17999355
|Title=A genomewide association study of skin pigmentation in a South Asian population.
|OA=1
}}

{{PMID Auto
|PMID=20042077
|Title=Genetic determinants of hair and eye colours in the Scottish and Danish populations.
|OA=1
}}

{{PMID Auto
|PMID=20670983
|Title=The Multiple Sclerosis Severity Score: associations with MC1R single nucleotide polymorphisms and host response to ultraviolet radiation.
}}

{{PMID Auto
|PMID=21052032
|Title=Sequence polymorphisms of MC1R gene and their association with depression and antidepressant response.
}}

{{PMID Auto
|PMID=23744330
|Title=[Association study of MC1R gene polymorphisms with freckles in Chinese Han population from Chengdu]
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}