{{Rsnum
|rsid=2229094
|Gene=LTA
|Chromosome=6
|position=31572779
|Orientation=plus
|GMAF=0.2677
|Gene_s=HLA-DQA1,LTA
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 3.5 | 43.4 | 53.1
| HCB | 8.0 | 26.3 | 65.7
| JPT | 0.9 | 26.5 | 72.6
| YRI | 8.8 | 38.8 | 52.4
| ASW | 12.3 | 42.1 | 45.6
| CHB | 8.0 | 26.3 | 65.7
| CHD | 4.6 | 36.7 | 58.7
| GIH | 14.9 | 48.5 | 36.6
| LWK | 10.9 | 40.9 | 48.2
| MEX | 12.1 | 36.2 | 51.7
| MKK | 5.8 | 37.8 | 56.4
| TSI | 11.8 | 41.2 | 47.1
| HapMapRevision=28
}}Associated with at least one "mortality outcome" in a study of ~10,000 individuals.{{PMID|18263601}}

{{PMID|18700950|OA=1
}}  827 males and 709 females, 606 subjects without cancer and 930 subjects with various [[cancer]]s 
*[[rs2229094]](A;A) (T495C, C13R) associated with gastric cancer (TC + CC: TT, adjusted OR = 1.68, 95% CI = 1.06 - 2.65)
in males but not in females

{{ neighbor
| rsid = 1041981
| distance = 228
}}

{{PMID Auto
|PMID=20177654
|Title=Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians
}}

{{PMID Auto
|PMID=20663564
|Title=A Strong Genetic Association between the Tumor Necrosis Factor Locus and Proliferative Vitreoretinopathy: The Retina 4 Project
}}

{{PMID Auto
|PMID=21628868
|Title=Haplotype-based association of four lymphotoxin-alpha gene polymorphisms with the risk of coronary artery disease in han chinese
}}

{{PMID Auto
|PMID=16839190
|Title=Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study.
|OA=1
}}

{{PMID Auto
|PMID=16846490
|Title=Lemierre's syndrome and genetic polymorphisms: a case report.
|OA=1
}}

{{PMID Auto
|PMID=17355643
|Title=Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.
|OA=1
}}

{{PMID Auto
|PMID=18398712
|Title=No association found between the promoter variants of TNF-alpha and diabetic retinopathy in Chinese patients with type 2 diabetes.
}}

{{PMID Auto
|PMID=18598365
|Title=Analytical approaches to detect maternal/fetal genotype incompatibilities that increase risk of pre-eclampsia.
|OA=1
}}

{{PMID Auto
|PMID=18687755
|Title=Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.
|OA=1
}}

{{PMID Auto
|PMID=18704761
|Title=Molecular genetics of myocardial infarction.
|OA=1
}}

{{PMID Auto
|PMID=18715339
|Title=Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.
|OA=1
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=19098314
|Title=Development of predictive models of proliferative vitreoretinopathy based on genetic variables: the Retina 4 project.
}}

{{PMID Auto
|PMID=20463618
|Title=Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.
|OA=1
}}

{{PMID Auto
|PMID=20811626
|Title=Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
|OA=1
}}

{{GET Evidence
|gene=LTA
|aa_change=Cys13Arg
|aa_change_short=C13R
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2229094
|overall_frequency_n=2056
|overall_frequency_d=7518
|overall_frequency=0.273477
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=32
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.003
|nblosum100=8
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23051989
|Title=Investigation of lymphotoxin alpha genetic variants in migraine.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}