{{Rsnum
|rsid=2230500
|Gene=PRKCH
|Chromosome=14
|position=61457521
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.0629
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PRKCH
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 0.0 | 100.0
| HCB | 0.0 | 5.2 | 94.8
| JPT | 0.0 | 2.7 | 97.3
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 5.2 | 94.8
| CHD | 0.0 | 5.5 | 94.5
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.9 | 99.1
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 1.0 | 99.0
| HapMapRevision=28
}}A common SNP only in Asian populations, this SNP (also known as 1425G/A) and a close neighbor also in the [[PRKCH]] gene, [[rs3783799]], have been associated with higher risk for subcortical silent brain infarction, a common form of [[stroke]].

In one study of ~1100 Japanese [[stroke]] patients, the odds ratio for carriers of the [[rs2230500]](A) risk allele was reported as 1.40 (CI: 1.23-1.59, p=5x10e-7).{{PMID|17206144}}

A subsequent study reported the odds ratio for carriers of the (A) allele as 1.27 (CI: 1.09-1.48, p=0.0026) compared to individuals homozygous for [[rs2230500]](G), based on studies of ~300 Japanese patients. {{PMID|18164711}}

{{PMID|19069168}} [[rs2230500]] (V374I) and [[rs9943582]] were significantly associated with [[stroke]]

{{PMID Auto
|PMID=19520989
|Title=The 1425G/A SNP in PRKCH Is Associated With Ischemic Stroke and Cerebral Hemorrhage in a Chinese Population
}}

{{omim
|id=605437
|desc=PROTEIN KINASE C, ETA; PRKCH
|rsnum=2230500
}}

{{PMID Auto
|PMID=20602195
|Title=PRKCH gene polymorphism is associated with the risk of severe gastric atrophy
}}

{{omim
|id=605437
|rsnum=2230500
|variant=0001
}}

{{ClinVar
|rsid=2230500
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=61924239
|CHROM=14
|GMAF=0.0627
|dbSNPBuildID=98
|SSR=0
|SAO=1
|VP=0x050368000000150517110100
|GENEINFO=PRKCH:5583
|GENE_NAME=PRKCH
|GENE_ID=5583
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000014.8:g.61924239G>A
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.9371; 0.0629
|CLNACC=RCV000005279.1
|CLNDBN=Cerebral infarction, susceptibility to
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=605437.0001
|COMMON=1
|Disease=Cerebral infarction
}}

{{PMID|17195206}} Genetic association between the PRKCH gene encoding protein kinase Ceta isozyme and rheumatoid arthritis in the Japanese population.

{{PMID|19703523}} Association of PRKCH gene with lacunar infarction in a local Chinese Han population.

{{PMID|21358133}} Genome-wide association study for ischemic stroke based on the hisayama study.

{{GET Evidence
|gene=PRKCH
|aa_change=Val374Ile
|aa_change_short=V374I
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2230500
|overall_frequency_n=68
|overall_frequency_d=10758
|overall_frequency=0.00632088
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|in_omim=Y
|nblosum100=-4
|autoscore=3
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}