{{Rsnum
|rsid=2230782
|Gene=NCOA3
|Chromosome=20
|position=47636144
|Orientation=plus
|GMAF=0.05785
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=NCOA3
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 1.5 | 23.1 | 75.4
| HCB | 0.0 | 6.7 | 93.3
| JPT | 0.0 | 6.8 | 93.2
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 6.7 | 93.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

[[rs2230782]], also known as Q586H, is a SNP in the nuclear receptor coactivator 3 [[NCOA3]] gene; this gene is also known as SRC-3 or AIB1.

A study of 1,218 familial BRCA1/2-mutation negative [[breast cancer]] cases and 1,509 matched controls strengthened a (previously reported) protective effect of [[rs2230782]]. The reported odds ratio for [[rs2230782]](C;C) homozygotes is 0.45 (CI: 0.21-0.98).{{PMID|20003447|OA=1
}}

{{PMID Auto
|PMID=19470168
|Title=NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.
|OA=1
}}

{{PMID Auto
|PMID=20180986
|Title=CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.
|OA=1
}}

{{GET Evidence
|gene=NCOA3
|aa_change=Gln586His
|aa_change_short=Q586H
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2230782
|overall_frequency_n=738
|overall_frequency_d=10758
|overall_frequency=0.0686001
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.004
|nblosum100=-1
|autoscore=1
|n_web_uneval=10
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}