{{Rsnum
|rsid=2230926
|Gene=TNFAIP3
|Chromosome=6
|position=137874929
|Orientation=plus
|GMAF=0.124
|Gene_s=TNFAIP3
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 0.0 | 5.3 | 94.7
| HCB | 0.0 | 11.7 | 88.3
| JPT | 2.7 | 15.9 | 81.4
| YRI | 21.1 | 48.3 | 30.6
| ASW | 12.3 | 29.8 | 57.9
| CHB | 0.0 | 11.7 | 88.3
| CHD | 0.9 | 11.9 | 87.2
| GIH | 0.0 | 6.9 | 93.1
| LWK | 6.4 | 57.3 | 36.4
| MEX | 0.0 | 3.4 | 96.6
| MKK | 12.2 | 44.9 | 42.9
| TSI | 0.0 | 7.8 | 92.2
| HapMapRevision=28
}}

Meta-analysis found 1.4x risk of [[rheumatoid arthritis]] for rs2230926(G;G) {{PMID|22402800}}

An association was found between Systemic lupus erythematosus ([[SLE]]) and [[rs2230926]].{{PMID|18677310}}

Three independent SNPs in the [[TNFAIP3]] region ([[rs13192841]], [[rs2230926]] and [[rs6922466]]) are associated with systemic lupus erythematosus ([[SLE]]) among individuals of European ancestry.{{PMID|19165919|OA=1
}}

{{ neighbor
| rsid = 5029939
| distance = 343
}}

{{omim
|desc=SYSTEMIC LUPUS ERYTHEMATOSUS, SUSCEPTIBILITY TO, 13; SLEB13
|id=612378
|rsnum=2230926
}}
{{PMID Auto
|PMID=19774492
|Title=A single-nucleotide polymorphism of the TNFAIP3 gene is associated with systemic lupus erythematosus in Chinese Han population
}}
{{PMID Auto GWAS
|PMID=19838193
|Trait=Systemic lupus erythematosus
|Title=Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus
|RiskAllele=C
|Pval=1E-17
|OR=1.72
|ORtxt=[1.52-1.94]
}}

{{PMID Auto
|PMID=20112363
|Title=The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population
}}

{{PMID Auto GWAS
|PMID=20453841
|Trait=Rheumatoid arthritis
|Title=A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
|RiskAllele=C
|Pval=0.000002
|OR=1.31
|ORtxt=[1.17-1.46]
}}
{{PMID Auto
|PMID=20617138
|Title=Association of TNFAIP3 Polymorphism with Susceptibility to Systemic Lupus Erythematosus in a Japanese Population
|OA=1
}}
{{PMID Auto
|PMID=21208380
|Title=The association between BANK1 and TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis
}}

{{PMID|19165918|OA=1
}} Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

{{PMID|19169254|OA=1
}} Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

{{PMID|19387456|OA=1
}} Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.

{{PMID|19417005|OA=1
}} Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23.

{{PMID|19439038|OA=1
}} Complex genetic association of 6q23 with autoimmune rheumatic conditions.

{{PMID|20169177|OA=1
}} Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.

{{PMID|21326317|OA=1
}} Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases.

{{PMID|22113471|OA=1
}} TNFAIP3 gene polymorphisms are associated with response to TNF blockade in psoriasis.

{{PMID|22402800}} Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis.

{{GET Evidence
|gene=TNFAIP3
|aa_change=Phe127Cys
|aa_change_short=F127C
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2230926
|overall_frequency_n=1531
|overall_frequency_d=10758
|overall_frequency=0.142313
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|pph2_score=0.049
|nblosum100=4
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23273568
  |Trait=Systemic lupus erythematosus
  |Title=Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
  |RiskAllele=G
  |Pval=1E-13
  |OR=2.71
  |ORtxt=
  |OA=1
}}

{{PMID Auto
|PMID=24023622
|Title=Analysis of Gender Differences in Genetic Risk: Association of TNFAIP3 Polymorphism with Male Childhood-Onset Systemic Lupus Erythematosus in the Japanese Population
|OA=1
}}

{{PMID Auto
|PMID=24159176
|Title=Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome
}}

{{PMID Auto
|PMID=23582631
|Title=Pathway analysis of genome-wide association studies on rheumatoid arthritis
}}

{{PMID Auto
|PMID=22488580
|Title=Brief report: candidate gene study in systemic sclerosis identifies a rare and functional variant of the TNFAIP3 locus as a risk factor for polyautoimmunity.
}}

{{PMID Auto
|PMID=22924496
|Title=Associations between TNFAIP3 gene polymorphisms and systemic lupus erythematosus: a meta-analysis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}