{{Rsnum
|rsid=2235544
|Gene=DIO1
|Chromosome=1
|position=53909897
|Orientation=plus
|GMAF=0.4449
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=DIO1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 31.0 | 46.9 | 22.1
| HCB | 21.9 | 51.1 | 27.0
| JPT | 12.4 | 51.3 | 36.3
| YRI | 1.4 | 25.2 | 73.5
| ASW | 8.8 | 31.6 | 59.6
| CHB | 21.9 | 51.1 | 27.0
| CHD | 25.7 | 51.4 | 22.9
| GIH | 34.7 | 53.5 | 11.9
| LWK | 3.6 | 27.3 | 69.1
| MEX | 48.3 | 41.4 | 10.3
| MKK | 1.3 | 32.1 | 66.7
| TSI | 14.7 | 55.9 | 29.4
| HapMapRevision=28
}}{{doi|10.1210/jc.2008-0397}} rs2235544, was associated with the free T3 to free T4 ratio with genome-wide levels of significance (P = 3.6 x 10â€“13). The C-allele of this SNP was associated with increased deiodinase 1 (D1) function with resulting increase in free T3/T4 ratio and free T3 and decrease in free T4 and rT3.

{{PMID|18492748|OA=1
}} A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine.

{{PMID|18815314|OA=1
}} Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.

{{PMID Auto GWAS
  |PMID=23408906
  |Trait=Thyroid hormone levels
  |Title=A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
  |RiskAllele=A
  |Pval=3E-18
  |OR=.13
  |ORtxt=[0.1-0.16] unit increase
  |OA=1
}}

{{PMID Auto GWAS
  |PMID=23502783
  |Trait=Multiple myeloma (hyperdiploidy)
  |Title=The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.
  |RiskAllele=A
  |Pval=6E-7
  |OR=1.30
  |ORtxt=[1.17-1.44]
  }}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}