{{Rsnum
|rsid=2235749
|Gene=PDYN
|Chromosome=20
|position=1979293
|Orientation=plus
|GMAF=0.4784
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PDYN,RP4-684O24.5
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 8.0 | 36.6 | 55.4
| HCB | 75.9 | 21.2 | 2.9
| JPT | 54.0 | 39.8 | 6.2
| YRI | 21.9 | 54.8 | 23.3
| ASW | 23.2 | 55.4 | 21.4
| CHB | 75.9 | 21.2 | 2.9
| CHD | 77.1 | 22.0 | 0.9
| GIH | 26.7 | 53.5 | 19.8
| LWK | 27.5 | 50.5 | 22.0
| MEX | 10.5 | 49.1 | 40.4
| MKK | 21.2 | 53.8 | 25.0
| TSI | 7.9 | 38.6 | 53.5
| HapMapRevision=28
}}{{PMID|18923396|OA=1
}}  In Caucasians, we found point-wise significant associations of 3' UTR SNPs ([[rs910080]], [[rs910079]], and [[rs2235749]]) with [[cocaine]] dependence and cocaine/[[alcohol]] codependence.

{{ neighbor
| rsid = 910079
| distance = 259
}}

{{PMID Auto
|PMID=21382455
|Title=Association between heroin dependence and prodynorphin gene polymorphisms
}}

{{PMID Auto
|PMID=21521424
|Title=Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}