{{Rsnum
|rsid=2236196
|Gene=CHRNA4
|Chromosome=20
|position=63346204
|Orientation=plus
|GMAF=0.337
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CHRNA4
}}{{omim
|desc=CHOLINERGIC RECEPTOR, NEURONAL NICOTINIC, ALPHA POLYPEPTIDE 4; CHRNA4
|id=118504
|rsnum=2236196
}}

{{PharmGKB
|RSID=rs2236196
|Name_s=
|Gene_s=CHRNA4
|Feature=
|Evidence=PubMed ID:19290018
|Annotation=The G allele of this polymorphism is associated with the intensification of nicotine dependence in a genetic association study in three large samples from the German general population (N1=1412; N2=1855; N3=2294). This variant is in the 3'-untranslated region of CHRNA4 gene.
|Drugs=nicotine
|Drug Classes=
|Diseases=Tobacco Use Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA164924602
}}

{{PMID Auto
|PMID=19482438
|Title=Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence
}}

{{PMID Auto
|PMID=22309839
|Title=Association study of 45 candidate genes in nicotine dependence in Han Chinese
}}

{{PMID Auto
|PMID=15154117
|Title=A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men.
|OA=1
}}

{{PMID Auto
|PMID=17135278
|Title=Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.
|OA=1
}}

{{PMID Auto
|PMID=17503330
|Title=A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=17768273
|Title=CHRNA4 and tobacco dependence: from gene regulation to treatment outcome.
}}

{{PMID Auto
|PMID=18165968
|Title=Identification of pharmacogenetic markers in smoking cessation therapy.
|OA=1
}}

{{PMID Auto
|PMID=18534558
|Title=Gene-gene interactions among CHRNA4, CHRNB2, BDNF, and NTRK2 in nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=18571741
|Title=Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.
|OA=1
}}

{{PMID Auto
|PMID=18593715
|Title=Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation.
|OA=1
}}

{{PMID Auto
|PMID=18618000
|Title=A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.
|OA=1
}}

{{PMID Auto
|PMID=18698231
|Title=Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.
|OA=1
}}

{{PMID Auto
|PMID=19029397
|Title=Nicotinic receptor gene variants influence susceptibility to heavy smoking.
|OA=1
}}

{{PMID Auto
|PMID=19238175
|Title=New insights into the genetics of addiction.
|OA=1
}}

{{PMID Auto
|PMID=19259974
|Title=Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.
|OA=1
}}

{{PMID Auto
|PMID=19693267
|Title=Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
|OA=1
}}

{{PMID Auto
|PMID=21445957
|Title=Association of CHRNA4 polymorphisms with smoking behavior in two populations.
|OA=1
}}

{{PMID Auto
|PMID=22180580
|Title=Association Between Nicotinic Acetylcholine Receptor Single Nucleotide Polymorphisms and Smoking Cessation.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2236196
|overall_frequency_n=57
|overall_frequency_d=106
|overall_frequency=0.537736
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=47
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}