{{Rsnum
|rsid=2236624
|Gene=ADORA2A
|Chromosome=22
|position=24440056
|Orientation=plus
|GMAF=0.2314
|Gene_s=ADORA2A,C22orf45
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 59.3 | 34.5 | 6.2
| HCB | 48.2 | 40.1 | 11.7
| JPT | 55.8 | 36.3 | 8.0
| YRI | 98.6 | 1.4 | 0.0
| ASW | 84.2 | 14.0 | 1.8
| CHB | 48.2 | 40.1 | 11.7
| CHD | 46.8 | 42.2 | 11.0
| GIH | 64.4 | 28.7 | 6.9
| LWK | 86.4 | 13.6 | 0.0
| MEX | 70.7 | 27.6 | 1.7
| MKK | 60.3 | 34.0 | 5.8
| TSI | 58.8 | 31.4 | 9.8
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2236624
|Name_s=ADORA2A: g.4226593T>C
|Gene_s=ADORA2A
|Feature=
|Evidence=PubMed ID:18539621
|Annotation=Risk or phenotype-associated allele: rs2236624 T allele. Phenotype: Carriers of 1 or 2 copies of the T allele for rs2236624 showed increased risk of any (OR = 2.73, CI 1.4-5.39, p = 0.002) or gastrointestinal-specific (OR = 2.7, CI = 1.02-7.49, p = 0.04) adverse events. Study size: 309 RA patients, including 147 good MTX responders, 101 MTX inefficacy failures, and 61 adverse event (AE) MTX failures (e.g. gastrointestinal (n = 24), abnormal liver function tests (n = 20), haematological (n = 7), skin rashes (n = 6), and other (n = 17). Study population/ethnicity: Rheumatoid arthritis (RA) patients aged over 18 yrs, of White Caucasian ethnic origin, classified as having RA according to ARA criteria that were retrospectively recruited from University Hospital of North Staffordshire (UHNS) and Central Manchester and Manchester Children&apos;s University Hospitals Trust (CMMC) in England. Significance metric(s): OR = 2.7, p = 0.002-0.04. Type of association: GN; PD; TOX; ADR.
|Drugs=methotrexate
|Drug Classes=
|Diseases=Arthritis, Rheumatoid; Drug Toxicity
|Curation Level=Curated
|PharmGKB Accession ID=PA165110744
}}
{{PMID Auto
|PMID=21088442
|Title=Variants of the Adenosine A(2A) Receptor Gene Are Protective against Proliferative Diabetic Retinopathy in Patients with Type 1 Diabetes
|OA=1
}}

{{PMID|18305461|OA=1
}} Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety.

{{PMID|19565319}} Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2236624
|overall_frequency_n=109
|overall_frequency_d=128
|overall_frequency=0.851562
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=94
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24943643
|Title=Association of Adenosine Receptor Gene Polymorphisms and in vivo Adenosine A1 Receptor Binding in the Human Brain
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}