{{Rsnum
|rsid=2237892
|Gene=KCNQ1
|Chromosome=11
|position=2818521
|Orientation=plus
|GMAF=0.1699
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=KCNQ1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 85.0 | 15.0 | 0.0
| HCB | 43.8 | 46.7 | 9.5
| JPT | 37.2 | 44.2 | 18.6
| YRI | 80.3 | 19.0 | 0.7
| ASW | 84.2 | 15.8 | 0.0
| CHB | 43.8 | 46.7 | 9.5
| CHD | 41.3 | 49.5 | 9.2
| GIH | 98.0 | 2.0 | 0.0
| LWK | 79.1 | 20.9 | 0.0
| MEX | 63.8 | 31.0 | 5.2
| MKK | 73.1 | 26.3 | 0.6
| TSI | 90.2 | 9.8 | 0.0
| HapMapRevision=28
}}

[http://blog.23andme.com/2008/08/18/snpwatch-snps-in-ion-channel-genes-are-associated-with-type-2-diabetes-and-bipolar-disorder/ 23andMe blog] rs2237892(C) is associated with an increased risk for developing [[type-2 diabetes]].

each C at rs2237892 increased the odds of type 2 diabetes by 1.4 times, compared to the TT genotype. Itâ€™s important to note, however, that the C version is actually pretty common.

In Asian populations, the C version of rs2237892 increased a personâ€™s odds of type 2 diabetes by 1.42 times compared to people with TT. But because about 50% of the Asian population is actually CT at this SNP, it could be viewed that CC has 1.3 times the odds compared to typical, while TT has 0.61 times the typical odds.

In European populations, about 85% of people are CC. This means that the results of Yasuda et al really show that compared to most Europeans, people with CT at rs2237892 have 0.78 times the typical odds of developing type 2 diabetes, and the odds for people with TT are 0.52 times typical.

{{PMID Auto
|PMID=19366866
|Title=Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion
|OA=1
}}

{{PMID Auto GWAS
|PMID=18711367
|Trait=Type 2 diabetes
|Title=Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
|RiskAllele=C
|Pval=2E-42
|OR=1.40
|ORtxt=[1.34-1.47]
}}
{{PMID Auto GWAS
|PMID=19401414
|Trait=Type 2 diabetes
|Title=Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
|RiskAllele=C
|Pval=1E-26
|OR=1.33
|ORtxt=[1.27-1.41]
|OA=1
}}
{{PMID Auto
|PMID=19448982
|Title=Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China
|OA=1
}}
{{PMID Auto
|PMID=19516902
|Title=The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load
|OA=1
}}

{{PMID Auto
|PMID=19575309
|Title=Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population
}}

{{omim
|desc=DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
|id=125853
|rsnum=2237892
}}
{{PMID Auto
|PMID=19308350
|Title=Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population
}}
{{PMID Auto
|PMID=19850681
|Title=Association of KCNQ1 Polymorphisms with the Gestational Diabetes Mellitus in Korean Women
}}

{{PharmGKB
|RSID=rs2237892
|Name_s=
|Gene_s=KCNQ1
|Feature=
|Evidence=PubMed ID:18711367; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. (Initial Sample Size: 187 Japanese cases, 1,504 Japanese controls; Replication Sample Size: 6,552 Asian cases, 6,621 Asian controls, 2,830 cases, 3,740 controls (Swedish)); (Region: 11p15.5; Reported Gene(s): KCNQ1; Risk Allele: rs2237892-C); (p-value= 2E-42).This variant is associated with Type 2 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740858
}}

{{PMID Auto
|PMID=20512086
|Title=Variants in KCNQ1, AP3S1, MAN2A1, and ALDH7A1 and the risk of type 2 diabetes in the Chinese Northern Han population: A case-control study and meta-analysis
}}

{{PMID Auto GWAS
|PMID=21573907
|Trait=None
|Title=Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.
|RiskAllele=C
|Pval=0.000004
|OR=1.2000
|ORtxt=[1.11-1.29]
|OA=1
}}

{{PMID Auto
|PMID=22403629
|Title=Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp
|OA=1
}}

{{PMID Auto
|PMID=22479571
|Title=Several Polymorphisms of KCNQ1 Gene Are Associated with Plasma Lipid Levels in General Chinese Populations
|OA=1
}}

{{PMID Auto
|PMID=22206064
|Title=KCNQ1 variants associate with type 2 diabetes in Malaysian Malay subjects
}}

{{PMID Auto
|PMID=22693455
|Title=Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
|OA=1
}}

{{PMID|18991055}} Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.

{{PMID|19033397|OA=1
}} Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening.

{{PMID|19252135|OA=1
}} Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore.

{{PMID|19323962|OA=1
}} Genome-wide association studies in type 2 diabetes.

{{PMID|19460916|OA=1
}} Genetic architecture of type 2 diabetes: recent progress and clinical implications.

{{PMID|19526209|OA=1
}} Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

{{PMID|19556355}} Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

{{PMID|19741467}} Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

{{PMID|19750184|OA=1
}} Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

{{PMID|19862325|OA=1
}} PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

{{PMID|20043853|OA=1
}} Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.

{{PMID|20509872|OA=1
}} Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.

{{PMID|20606385}} Polymorphisms in KCNQ1 are associated with gestational diabetes in a Korean population.

{{PMID|20701788|OA=1
}} KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population.

{{PMID|21261977|OA=1
}} Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US.

{{PMID|21278902|OA=1
}} Genetic risk profiling for prediction of type 2 diabetes.

{{PMID|21289621}} Effects of KCNQ1 polymorphisms on the therapeutic efficacy of oral antidiabetic drugs in Chinese patients with type 2 diabetes.

{{PMID|22377712}} Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.

{{PMID|22377714}} Impact of common type 2 diabetes risk gene variants on future type 2 diabetes in the non-diabetic population in Korea.

{{PMID|22414228}} KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese Type 2 diabetic patients.

{{PMID|22461567|OA=1
}} Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2237892
|overall_frequency_n=10
|overall_frequency_d=126
|overall_frequency=0.0793651
|n_genomes=9
|n_genomes_annotated=0
|n_haplomes=9
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23133642
|Title=The Association between KCNQ1 Gene Polymorphism and Type 2 Diabetes Risk: A Meta-Analysis
|OA=1
}}

{{PMID Auto
|PMID=23271129
|Title=Meta-analysis of the effect of KCNQ1 gene polymorphism on the risk of type 2 diabetes
}}

{{PMID Auto
|PMID=23029294
|Title=Meta-analysis of the relationship between common type 2 diabetes risk gene variants with gestational diabetes mellitus
|OA=1
}}

{{PMID Auto GWAS
  |PMID=22961080
  |Trait=Type 2 diabetes
  |Title=A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
  |RiskAllele=C
  |Pval=1E-7
  |OR=1.32
  |ORtxt=[1.19-1.46]
  |OA=1
}}

{{PMID Auto
|PMID=23786590
|Title=Common Variants in KCNQ1 Confer Increased Risk of Type 2 Diabetes and Contribute to the Diabetic Epidemic in East Asians: A Replication and Meta-Analysis
}}

{{PMID Auto
|PMID=22790062
|Title=Association between KCNQ1 genetic variants and obesity in Chinese patients with type 2 diabetes.
}}

{{PMID Auto
|PMID=22923468
|Title=Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
|OA=1
}}

{{PMID Auto
|PMID=23107108
|Title=Lack of association between genetic polymorphisms within KCNQ1 locus and type 2 diabetes in Tunisian Arabs.
}}

{{PMID Auto
|PMID=23630301
|Title=Strong parent-of-origin effects in the association of KCNQ1 variants with type 2 diabetes in American Indians.
}}

{{PMID Auto
|PMID=23692438
|Title=Association between KCNQ1 genetic variants and QT interval in a Chinese population.
}}

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{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}