{{Rsnum
|rsid=2237897
|Gene=KCNQ1
|Chromosome=11
|position=2837316
|Orientation=plus
|GMAF=0.1589
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=KCNQ1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 90.6 | 9.4 | 0.0
| HCB | 0.0 | 0.0 | 0.0
| JPT | 0.0 | 0.0 | 0.0
| YRI | 0.0 | 0.0 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[http://www.nature.com/ng/journal/vaop/ncurrent/abs/ng.208.html nature] [[type-2 diabetes]] 
*[[rs2237897]], P = 6.8 times 10-13; OR = 1.41, 95% CI = 1.29â€“1.55)

A study of 754 [[type-2 diabetes]] patients plus a meta-analysis concluded that [[rs2237897]](T) was significantly associated with susceptibility to diabetic nephropathy in T2D Japanese subjects (odds ratio = 1.22, CI: 1.10-1.34, corrected p = 0.01).{{PMID|20056949|OA=1
}}

{{PMID Auto
|PMID=19366866
|Title=Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion
|OA=1
}}
{{PMID Auto GWAS
|PMID=18711366
|Trait=Type 2 diabetes
|Title=SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
|RiskAllele=C
|Pval=1E-16
|OR=1.33
|ORtxt=[1.24-1.41]
}}
{{PMID Auto
|PMID=19448982
|Title=Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China
|OA=1
}}
{{PMID Auto
|PMID=19516902
|Title=The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load
|OA=1
}}

{{PMID Auto
|PMID=19575309
|Title=Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population
}}
{{PMID Auto
|PMID=19308350
|Title=Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population
}}

{{PharmGKB
|RSID=rs2237897
|Name_s=
|Gene_s=KCNQ1
|Feature=
|Evidence=PubMed ID:18711366; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. (Initial Sample Size: 194 Japanese cases, 1,558 Japanese controls; Replication Sample Size: 4,924 cases, 2,618 controls (Japanese), 1433 cases, 1,735 controls (Singaporean), 3,891 cases, 4,888 controls (Danish)); (Region: 11p15.4; Reported Gene(s): KCNQ1; Risk Allele: rs2237897-C); (p-value= 0.0000000000000001).This variant is associated with Type 2 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740855
}}

{{PMID|19252135|OA=1
}} Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore.

{{PMID|19556355}} Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

{{PMID|20174558|OA=1
}} A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.

{{PMID|20701788|OA=1
}} KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population.

{{PMID|21261977|OA=1
}} Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US.

{{PMID|21289621}} Effects of KCNQ1 polymorphisms on the therapeutic efficacy of oral antidiabetic drugs in Chinese patients with type 2 diabetes.

{{PMID|21767287}} Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort.

{{PMID Auto
|PMID=22696034
|Title=KCNQ1 SNPS and susceptibility to diabetic nephropathy in East Asians with type 2 diabetes.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2237897
|overall_frequency_n=12
|overall_frequency_d=122
|overall_frequency=0.0983607
|n_genomes=10
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23271129
|Title=Meta-analysis of the effect of KCNQ1 gene polymorphism on the risk of type 2 diabetes
}}

{{PMID Auto
|PMID=23786590
|Title=Common Variants in KCNQ1 Confer Increased Risk of Type 2 Diabetes and Contribute to the Diabetic Epidemic in East Asians: A Replication and Meta-Analysis
}}

{{PMID Auto
|PMID=23298195
|Title=Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.
}}

{{PMID Auto
|PMID=23544998
|Title=Association of TRPC1 gene polymorphisms with type 2 diabetes and diabetic nephropathy in Han Chinese population.
|OA=1
}}

{{PMID Auto GWAS
  |PMID=24390345
  |Trait=Type 2 diabetes
  |Title=Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
  |RiskAllele=C
  |Pval=9E-15
  |OR=1.31
  |ORtxt=[1.22-1.41]
  }}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}