{{Rsnum
|rsid=2239704
|Gene=LTA
|Chromosome=6
|position=31572364
|Orientation=minus
|GMAF=0.3476
|Gene_s=HLA-DQA1,LTA
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 33.6 | 50.4 | 15.9
| HCB | 44.5 | 45.3 | 10.2
| JPT | 32.7 | 45.1 | 22.1
| YRI | 52.4 | 38.8 | 8.8
| ASW | 49.1 | 43.9 | 7.0
| CHB | 44.5 | 45.3 | 10.2
| CHD | 46.8 | 47.7 | 5.5
| GIH | 35.6 | 52.5 | 11.9
| LWK | 65.1 | 33.9 | 0.9
| MEX | 26.3 | 56.1 | 17.5
| MKK | 67.9 | 28.2 | 3.8
| TSI | 29.4 | 58.8 | 11.8
| HapMapRevision=28
}}
{{omim
|id=153440
|desc=LYMPHOTOXIN-ALPHA; LTA
|rsnum=2239704
}}

A US study {{PMID|17018637}} of 1,172 [[lymphoma]] patients and 982 controls looked at 57 SNPs in 36 immune function genes. Five SNPs in two [[cytokine]] genes, [[TNF]] and [[LTA]], were associated with a 1.31x increase in [[Non-Hodgkin Lymphoma]] (OR, 1.31; 95% CI, 1.06-1.63; P = 0.01) and with a 1.64x increase in the subtype known as [[diffuse large B cell lymphoma]] (OR, 1.64; 95% CI, 1.23-2.19; P = 0.0007). The other four SNPS are listed below. The cytokine genes affect inflammatory and innate immune responses.

* [[rs1800629]]
* [[rs361525]]
* [[rs1799724]]
* [[rs909253]]

{{omim
|id=153440
|rsnum=2239704
|variant=0003
}}

{{PMID Auto
|PMID=21628868
|Title=Haplotype-based association of four lymphotoxin-alpha gene polymorphisms with the risk of coronary artery disease in han chinese
}}

{{PMID Auto
|PMID=16449530
|Title=Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=17327408
|Title=Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
|OA=1
}}

{{PMID Auto
|PMID=17450233
|Title=Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma.
|OA=1
}}

{{PMID Auto
|PMID=18633131
|Title=Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
|OA=1
}}

{{PMID Auto
|PMID=18687755
|Title=Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.
|OA=1
}}

{{PMID Auto
|PMID=18715339
|Title=Associations between cytokine/cytokine receptor single nucleotide polymorphisms and humoral immunity to measles, mumps and rubella in a Somali population.
|OA=1
}}

{{PMID Auto
|PMID=18805939
|Title=Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
|OA=1
}}

{{PMID Auto
|PMID=18990758
|Title=Genetic variation in tumor necrosis factor and the nuclear factor-kappaB canonical pathway and risk of non-Hodgkin's lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19066394
|Title=Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=19281305
|Title=Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.
|OA=1
}}

{{PMID Auto
|PMID=20617178
|Title=Leprosy and the adaptation of human toll-like receptor 1.
|OA=1
}}

{{PMID Auto
|PMID=23824834
|Title=Genetic variation in the TLR and NF-κB genetic pathways and cervical and vulvar cancer risk: A population-based case-control study
}}

{{PMID Auto
|PMID=23071570
|Title=Gene-gene interaction and functional impact of polymorphisms on innate immune genes in controlling Plasmodium falciparum blood infection level.
|OA=1
}}

{{PMID Auto
|PMID=23647060
|Title=Candidate gene association studies and risk of chronic lymphocytic leukemia: a systematic review and meta-analysis.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}