{{Rsnum
|rsid=2240308
|Gene=AXIN2
|Chromosome=17
|position=65558473
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.348
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=AXIN2,LOC102724272
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 25.7 | 45.1 | 29.2
| HCB | 13.1 | 43.1 | 43.8
| JPT | 8.8 | 42.5 | 48.7
| YRI | 0.7 | 3.4 | 95.9
| ASW | 8.8 | 26.3 | 64.9
| CHB | 13.1 | 43.1 | 43.8
| CHD | 8.3 | 47.7 | 44.0
| GIH | 15.8 | 45.5 | 38.6
| LWK | 0.9 | 15.6 | 83.5
| MEX | 19.0 | 62.1 | 19.0
| MKK | 0.6 | 14.2 | 85.2
| TSI | 16.7 | 47.1 | 36.3
| HapMapRevision=28
}}

{{Venter SNP
|rsid=2240308
|allele=A
|frequency=0.525
|uid=1103645362995
|type=homozygous_SNP
|hugo=AXIN2
|ensembl gene=ENSG00000168646
|ensembl transcript=ENST00000307078
|sift=TOLERATED
|disease=Defects in AXIN2 are the cause of oligodontia-colorectal cancer syndrome (MIM:608615). Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.
}}

{{PMID Auto
|PMID=19065536
|Title=[Association of single nucleotide polymorphisms of Axis inhibitor-2 gene rs224030, rs8081536, rs9913621 with Hirschsprung disease]
}}

{{PMID Auto
|PMID=21069480
|Title=AXIN2 polymorphism and its association with prostate cancer in a Turkish population
}}

{{PMID|18683894|OA=1
}} AXIN2 and CDH1 polymorphisms, tooth agenesis, and oral clefts.

{{PMID|18790474|OA=1
}} Axis inhibition protein 2 (AXIN2) polymorphisms and tooth agenesis.

{{GET Evidence
|gene=AXIN2
|aa_change=Pro50Ser
|aa_change_short=P50S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2240308
|overall_frequency_n=4190
|overall_frequency_d=10758
|overall_frequency=0.389478
|n_genomes=28
|n_genomes_annotated=0
|n_haplomes=38
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=3
|autoscore=2
|n_web_uneval=4
}}

{{PMID Auto
|PMID=24078348
|Title=An Analysis of Polymorphisms Within the Wnt Signaling Pathway in Relation to Ovarian Cancer Risk in a Polish Population
|OA=1
}}

{{PMID Auto
|PMID=25013500
|Title=Significant association between the Axin2 rs2240308 single nucleotide polymorphism and the incidence of prostate cancer
}}

{{PMID Auto
|PMID=25091576
|Title=The Axin2 rs2240308 polymorphism and susceptibility to lung cancer in a Chinese population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}