{{Rsnum
|rsid=2240340
|Gene=PADI4
|Chromosome=1
|position=17336144
|Orientation=minus
|GMAF=0.4605
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PADI4
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 20.0 | 43.1 | 36.9
| HCB | 17.8 | 46.7 | 35.6
| JPT | 22.2 | 42.2 | 35.6
| YRI | 39.7 | 47.6 | 12.7
| ASW | 0.0 | 0.0 | 0.0
| CHB | 17.8 | 46.7 | 35.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
Several studies have all found that [[rs2240340]], a SNP in the [[PADI4]] gene, is associated with risk for developing [[rheumatoid arthritis]] (RA). The risk allele in dbSNP orientation is (T).

The largest study involved over 2,000 RA patients, and although implicating [[PTPN22]] SNPs with greater risk, [[PADI4]] SNP [[rs2240340]] was also implicated. The odds ratio varied between the two (European) populations a bit, but when combined, was 1.10 (CI: 1.00 - 1.21) for the risk allele. {{PMID|16380915|OA=1
}}

Additional studies include:

{{PMID|18087673}} [[rs2240340]] was modestly associated with [[rheumatoid arthritis]]in a study of 950 unrelated Japanese subjects with RA, with an odds ratio of 1.22 (CI: 1.04 - 1.43,p=0.012).

{{PMID|12833157}} [[rs2240340]] was associated with [[rheumatoid arthritis]] with an odds ratio of 1.97 (CI: 1.44 â€“ 2.69), based on 830 cases and 736 controls .

{{ neighbor
| rsid = 1748035
| distance = 643
}}
{{ neighbor
| rsid = 1748033
| distance = 23
}}

{{PMID Auto
|PMID=19470526
|Title=PADI4 genotype is not associated with rheumatoid arthritis in a large UK Caucasian Population
|OA=1
}}

{{PMID Auto
|PMID=20563870
|Title=The PADI4 gene does not contribute to genetic susceptibility to rheumatoid arthritis in Chinese Han population
}}

{{PMID Auto
|PMID=16519819
|Title=Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
|OA=1
}}

{{PMID Auto
|PMID=18462498
|Title=Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking.
|OA=1
}}

{{PMID Auto
|PMID=18466472
|Title=Constructing gene association networks for rheumatoid arthritis using the backward genotype-trait association (BGTA) algorithm.
|OA=1
}}

{{PMID Auto
|PMID=18466513
|Title=Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15.
|OA=1
}}

{{PMID Auto
|PMID=18466554
|Title=Analyses of single marker and pairwise effects of candidate loci for rheumatoid arthritis using logistic regression and random forests.
|OA=1
}}

{{PMID Auto
|PMID=18794853
|Title=Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=19180477
|Title=Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations.
|OA=1
}}

{{PMID Auto
|PMID=20444268
|Title=Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.
|OA=1
}}

{{PMID Auto
|PMID=21039740
|Title=PADI4 gene polymorphism is not associated with ankylosing spondylitis in Chinese Han population.
}}

{{PMID Auto
|PMID=22505706
|Title=Peptidylarginine deiminase type 4 and methyl-CpG binding domain 4 polymorphisms in Chinese patients with rheumatoid arthritis.
}}

{{PMID Auto
|PMID=23164236
|Title=Polymorphisms in peptidylarginine deiminase (PADI) associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis
|OA=1
}}

{{PMID Auto
|PMID=23450494
|Title=[Association of polymorphisms of PTPN22 and PADI4 genes with rheumatoid arthritis in Yunnan]
}}

{{PMID Auto
|PMID=24564960
|Title=Association between PADI4 gene polymorphisms and anti-cyclic citrullinated peptide antibody positive rheumatoid arthritis in a large Chinese Han cohort
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}