{{Rsnum
|rsid=224136
|Chromosome=10
|position=64470675
|Orientation=plus
|GMAF=0.3577
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 72.6 | 26.5 | 0.9
| HCB | 52.6 | 41.6 | 5.8
| JPT | 51.3 | 36.3 | 12.4
| YRI | 2.0 | 23.8 | 74.1
| ASW | 8.8 | 40.4 | 50.9
| CHB | 52.6 | 41.6 | 5.8
| CHD | 44.0 | 45.9 | 10.1
| GIH | 46.0 | 47.0 | 7.0
| LWK | 1.8 | 24.8 | 73.4
| MEX | 56.9 | 41.4 | 1.7
| MKK | 7.1 | 41.7 | 51.3
| TSI | 60.8 | 34.3 | 4.9
| HapMapRevision=28
}}{{Report GE
|PubMed=17435756
|Source=pubmed
|AffyProbeset=SNP_A-1883807
|AffyOrientation=reverse
|AlleleA=A
|AlleleB=G
|onGW5=1
|rsid=224136
|ancestral=T
|RiskPopulation=EU
|RiskAllele=C
|CaseFreq=0.87
|ControlFreq=0.81
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=1.67
|Disease=Crohn's disease
|DiseaseSymbol=CD
|OA=1
}}

Carriers of the C allele of [[rs224136]] reportedly have 1.67 times higher susceptibility to [[Crohn's disease]]. {{PMID|17435756|OA=1
}}

[[Rs224136]] is not a major genetic risk factor for susceptibility to Crohn's disease in the German population. {{PMID|19262523}} 

{{GWAS Summary
|SNP=rs224136
|PubMedID=17435756
|Condition=Crohn's disease
|Gene=Intergenic
|Risk Allele=
|pValue=1.00E-010
|OR=1.67
|95CI=
|OA=1
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 15; IBD15
|id=612255
|rsnum=224136
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 1; IBD1
|id=266600
|rsnum=224136
}}

{{PharmGKB
|RSID=rs224136
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17435756; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis (Initial Sample Size: 946 cases, 977 controls; Replication Sample Size: 530 trios, 353 cases, 207 controls). This variant is associated with Crohn's disease.
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356505
}}

{{PMID Auto
|PMID=17068223
|Title=A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
}}

{{PMID Auto
|PMID=20195480
|Title=The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=20222171
|Title=T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: a meta-analysis.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs224136
|overall_frequency_n=50
|overall_frequency_d=128
|overall_frequency=0.390625
|n_genomes=27
|n_genomes_annotated=0
|n_haplomes=45
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | Illumina Human 1M}}