{{Rsnum
|rsid=2241712
|Gene=B9D2
|Chromosome=19
|position=41363851
|Orientation=minus
|GMAF=0.3489
|Gene_s=B9D2,TMEM91
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}[[rs2241712]], a SNP in the promoter region of the transforming growth factor beta1 [[TGFB1]] gene has been associated with increased risk for [[chronic obstructive pulmonary disease]] (COPD). Although smoking is the main risk factor, smokers with a [[rs2241712]](A) allele (or 2 other [[TGFB1]] SNPs, [[rs1982073]] and [[rs1800469]]) were more likely to develop COPD, based on a study of ~700 Caucasian subjects {{PMID|15175276}}

{{PMID|19096005|OA=1
}} [[asthma]] rs2241712(A) and rs1800469(C) associated with increased airway responsiveness
{{PMID Auto
|PMID=22053598
|Title=Association of TGF-beta1, IL-4 and IL-13 gene polymerphisms with asthma in a Chinese population
}}{{PMID Auto
|PMID=16704031
|Title=Lack of association between COPD and transforming growth factor-beta1 (TGFB1) genetic polymorphisms in Koreans.
}}

{{PMID Auto
|PMID=17686149
|Title=Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery.
|OA=1
}}

{{PMID Auto
|PMID=18670143
|Title=The association of transforming growth factor beta 1 gene polymorphisms with the emphysema phenotype of COPD in Japanese.
}}

{{PMID Auto
|PMID=21320324
|Title=The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study.
|OA=1
}}

{{PMID Auto
|PMID=21556788
|Title=Lack of association between the TGF-beta(1) gene and development of COPD in Asians: a case-control study and meta-analysis.
}}
{{PMID Auto
|PMID=23267696
|Title=Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study
|OA=1
}}