{{Rsnum
|rsid=2241766
|Gene=ADIPOQ
|Chromosome=3
|position=186853103
|Orientation=plus
|ReferenceAllele=T
|GMAF=0.1446
|Gene_s=ADIPOQ,ADIPOQ-AS1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}A study of 733 [[breast cancer]] cases for 10 SNPs concluded that the [[rs2241766]](G;T) genotype, in combination with certain genotypes at [[rs1501299]], was at reduced risk (odds ratio 0.61, CI: 0.46-0.80). After categorizing individuals by adiponectin signaling status, this study found that compared with high signalers, intermediate signalers had a 4.16-fold increase in breast cancer risk (CI: 0.49-35.19), and low signalers had a 6.56x higher [[breast cancer]] risk (CI: 0.78-54.89, p(trend) = 0.001).{{PMID|18451143|OA=1
}}

Adiponectin signaling status was assigned as follows:

[[rs1501299]](G,G) + [[rs2241766]](T,T) = low signaler<br>
rs1501299(G,T) + rs2241766(T,T) = low signaler<br>
rs1501299(G,G) + rs2241766(G,T) = low signaler<br>
rs1501299(T,T) + rs2241766(T,T) = intermediate signaler<br>
rs1501299(G,T) + rs2241766(G,T) = intermediate signaler<br>
rs1501299(G,G) + rs2241766(G,G) = intermediate signaler<br>
rs1501299(G,T) + rs2241766(G,G) = high signaler<br>
rs1501299(T,T) + rs2241766(G,G) = high signaler<br>
rs1501299(T,T) + rs2241766(G,T) = high signaler<br>

Based on these criteria, adiponectin signaling status is now determined by genosets Gs119 and Gs120 for Promethease users.

Note that [http://en.wikipedia.org/wiki/Adiponectin adiponectin], a hormone produced by adipose tissue (body fat), is involved in lipid metabolism.

In other words, you are a low adiponectin signaler, and thus possibly at 6-fold higher risk of breast cancer, if you have one of these combinations of alleles:
*[[rs1501299]]  GG and also [[rs2241766]] either GT or TT
*[[rs1501299]]  GT and also [[rs2241766]] TT

You are an intermediate adiponectin signaler, and thus possibly at 4-fold higher risk of breast cancer, if you have one of these combinations of alleles:
* [[rs1501299]] GG and also [[rs2241766]] GG
* [[rs1501299]] GT and also [[rs2241766]] GT
* [[rs1501299]] TT and also [[rs2241766]] TT

You are a high adiponectin signaler if you have one of these combinations of alleles:
* [[rs1501299]] GT and also [[rs2241766]] GG
* [[rs1501299]] TT and also [[rs2241766]] either GG or GT

{{ neighbor
| rsid = 1501299
| distance = 231
}}

{{PMID Auto
|PMID=19573164
|Title=Association Study and Mutation Analysis of Adiponectin Shows Association of Variants in APM1 with Complex Obesity in Women
}}

{{omim
|desc=ADIPONECTIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1; ADIPQTL1
|id=612556
|rsnum=2241766
}}

{{omim
|desc=ADIPOCYTE-, C1q-, AND COLLAGEN DOMAIN-CONTAINING; ADIPOQ
|id=605441
|rsnum=2241766
}}
{{PMID Auto
|PMID=19696691
|Title=Low Serum Adiponectin Levels Are Associated With Systemic Organ Failure in Acute Pancreatitis
}}
{{PMID Auto
|PMID=19631916
|Title=Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese
}}

{{PMID Auto
|PMID=20414354
|Title=Analysis of adiponectin gene polymorphisms in chinese population with systemic lupus erythematosus
|OA=1
}}
{{PMID Auto
|PMID=20576642
|Title=Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population
}}
{{PMID Auto
|PMID=20664545
|Title=Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases
}}

{{PMID Auto
|PMID=21397927
|Title=Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk
|OA=1
}}

{{PMID Auto
|PMID=21516303
|Title=Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes
|OA=1
}}

{{PMID Auto
|PMID=21619462
|Title=The role of adiponectin (ADIPOQ) gene polymorphisms in the susceptibility and prognosis of non-small cell lung cancer
}}

{{PMID Auto
|PMID=21630088
|Title=Genetic effects of adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults
}}

{{PMID Auto
|PMID=21637951
|Title=A common variant in the adiponectin gene and polycystic ovary syndrome risk
}}

{{PMID Auto
|PMID=21726267
|Title=A Meta-analysis on the Association of Adiponectin Gene Polymorphisms with Coronary Heart Disease in Chinese Han Population
}}

{{PMID Auto
|PMID=22459242
|Title=Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects
}}

{{PMID Auto
|PMID=22673923
|Title=An Association Study of SNP + 45 T &gt; G of the AdipoQ Gene with Type 2 Diabetes in Yi and Han People in China
}}

{{PMID Auto
|PMID=22714914
|Title=Common polymorphisms (rs2241766 and rs1501299) in the ADIPOQ gene are not associated with hypertension susceptibility among the Chinese
}}

{{PMID Auto
|PMID=15616038
|Title=Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene.
}}

{{PMID Auto
|PMID=16990411
|Title=Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study.
}}

{{PMID Auto
|PMID=17357083
|Title=Medical sequencing at the extremes of human body mass.
|OA=1
}}

{{PMID Auto
|PMID=17712123
|Title=Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women.
}}

{{PMID Auto
|PMID=18523726
|Title=Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity.
|OA=1
}}

{{PMID Auto
|PMID=18548168
|Title=Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=18603647
|Title=Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
|OA=1
}}

{{PMID Auto
|PMID=18716158
|Title=Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.
|OA=1
}}

{{PMID Auto
|PMID=18776141
|Title=Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.
|OA=1
}}

{{PMID Auto
|PMID=18827209
|Title=Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19035456
|Title=Adipokine genes and prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19037660
|Title=The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.
|OA=1
}}

{{PMID Auto
|PMID=19238139
|Title=ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study.
|OA=1
}}

{{PMID Auto
|PMID=19661719
|Title=Interaction of ADIPOQ genetic polymorphism with blood pressure and plasma cholesterol level on the risk of coronary artery disease.
}}

{{PMID Auto
|PMID=19755407
|Title=Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women.
|OA=1
}}

{{PMID Auto
|PMID=19912668
|Title=Design and evaluation of a treatment programme for Spanish adolescents with overweight and obesity. The EVASYON Study.
|OA=1
}}

{{PMID Auto
|PMID=20201642
|Title=Associations of polymorphisms in adiponectin and leptin genes with men's longevity.
}}

{{PMID Auto
|PMID=20230294
|Title=Analysis of adiponectin gene polymorphisms in dilated cardiomyopathy in a Han Chinese population.
}}

{{PMID Auto
|PMID=20848215
|Title=Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population.
}}

{{PMID Auto
|PMID=21054480
|Title=Genetic effects of adiponectin on blood lipids and blood pressure.
}}

{{PMID Auto
|PMID=21219602
|Title=Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.
|OA=1
}}

{{PMID Auto
|PMID=21623778
|Title=Adiponectin in chronic heart failure: influence of diabetes and genetic variants.
}}

{{PMID Auto
|PMID=21638131
|Title=Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.
}}

{{PMID Auto
|PMID=22070425
|Title=Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.
}}

{{PMID Auto
|PMID=22386722
|Title=Association of ADIPOQ gene polymorphisms and coronary artery disease risk: a meta-analysis based on 12 465 subjects.
}}

{{PMID Auto
|PMID=22391941
|Title=Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population.
}}

{{PMID Auto
|PMID=22583123
|Title=Association of TCF7L2 and ADIPOQ with Body Mass Index, Waist-Hip Ratio, and Systolic Blood Pressure in an Endogamous Ethnic Group of India.
|OA=1
}}

{{PMID Auto
|PMID=23041095
|Title=Genetic variability on adiponectin gene affects myocardial infarction risk: The role of endothelial dysfunction
}}

{{PMID Auto
|PMID=23118546
|Title=Association of ADIPOQ +45T&gt;G polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a Mexican-Mestizo population
|OA=1
}}

{{PMID Auto
|PMID=23143890
|Title=Adiponectin (ADIPOQ) rs2241766 G/T polymorphism is associated with risk of cancer: evidence from a meta-analysis
}}

{{PMID Auto
|PMID=23151860
|Title=+276 G/T single nucleotide polymorphism of the adiponectin gene is associated with the susceptibility to biliary atresia
}}

{{PMID Auto
|PMID=23200411
|Title=ADIPOQ gene polymorphisms and cancer risk: A meta-analysis
}}

{{PMID Auto
|PMID=23370338
|Title=Adiponectin gene polymorphisms may not be associated with idiopathic premature ovarian failure
}}

{{PMID Auto
|PMID=23653335
|Title=AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study
}}

{{PMID Auto
|PMID=23658423
|Title=Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals
}}

{{PMID Auto
|PMID=23740135
|Title=The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk
}}

{{PMID Auto
|PMID=23803590
|Title=Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia
}}

{{PMID Auto
|PMID=23260797
|Title=Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes
}}

{{PMID Auto
|PMID=23805506
|Title=[Association of adiponectin gene polymorphrism with metabolic syndrome in older Han adults from major cities in China]
}}

{{PMID Auto
|PMID=23819115
|Title=Association of Atherosclerotic Peripheral Arterial Disease with Adiponectin Genes SNP+45 and SNP+276: A Case-Control Study
|OA=1
}}

{{PMID Auto
|PMID=23826253
|Title=Gene Polymorphisms of ADIPOQ +45T&gt;G, UCP2 -866G&gt;A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study
|OA=1
}}

{{PMID Auto
|PMID=23972466
|Title=Association Between the Adiponectin +45T&gt;G Genotype and Risk of Cardiovascular Disease: A Meta-analysis
}}

{{PMID Auto
|PMID=24293390
|Title=An updated meta-analysis of the association between ADIPOQ rs2241766 polymorphism and colorectal cancer
}}

{{PMID Auto
|PMID=24559720
|Title=Family-based analysis of adiponectin gene polymorphisms in Chinese Han polycystic ovary syndrome
}}

{{PMID Auto
|PMID=23065236
|Title=The roles of ADIPOQ genetic variations in cancer risk: evidence from published studies.
}}

{{PMID Auto
|PMID=23144319
|Title=Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
}}

{{PMID Auto
|PMID=23144325
|Title=P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.
|OA=1
}}

{{PMID Auto
|PMID=23552441
|Title=Association of adiponectin gene polymorphism with birth weight in Korean neonates.
}}

{{PMID Auto
|PMID=24894086
|Title=Adiponectin gene (ADIPOQ) polymorphisms correlate with the progression of nephropathy in Taiwanese male patients with type 2 diabetes
}}

{{PMID Auto
|PMID=25074391
|Title=Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents
}}

{{PMID Auto
|PMID=25135112
|Title=Assessment of type 2 diabetes risk conferred by SNPs rs2241766 and rs1501299 in the ADIPOQ gene, a case/control study combined with meta-analyses
}}

{{PMID Auto
|PMID=25223469
|Title=Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}