{{Rsnum
|rsid=2242047
|Gene=SLC28A1
|Chromosome=15
|position=84935465
|Orientation=minus
|GMAF=0.118
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SLC28A1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.0 | 3.5 | 96.5
| HCB | 13.9 | 43.1 | 43.1
| JPT | 15.9 | 36.3 | 47.8
| YRI | 0.0 | 17.0 | 83.0
| ASW | 0.0 | 14.0 | 86.0
| CHB | 13.9 | 43.1 | 43.1
| CHD | 16.5 | 45.9 | 37.6
| GIH | 0.0 | 10.9 | 89.1
| LWK | 0.9 | 14.5 | 84.5
| MEX | 0.0 | 5.2 | 94.8
| MKK | 0.0 | 14.7 | 85.3
| TSI | 0.0 | 3.9 | 96.1
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2242047
|Name_s=SLC28A1:1543G>A, R510C
|Gene_s=SLC28A1
|Feature=Exon/NonSyn
|Evidence=PubMed ID:15224082
|Annotation=Risk or phenotype-associated allele: None. Phenotype: Variants identified in a screen of 13 genes involved in the gemcitabine drug metabolic pathway. For the non-synonymous SLC28A1:1543G>A (R510C) SNP, the A (510Cys) allele was at frequency was 0.02 and 0.09 in Europeans and Africans, respectively. There was a significant difference between ethnic groups in genotype frequency distribution (p < 0.05). Study size: 186. Study population/ethnicity: Healthy, unrelated blood donors of European (n = 93) and African (n = 93) descent. Significance metric(s): p < 0.05. Type of association: GN.
|Drugs=gemcitabine
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA165110721
}}

{{GET Evidence
|gene=SLC28A1
|aa_change=Arg510Cys
|aa_change_short=R510C
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2242047
|overall_frequency_n=444
|overall_frequency_d=10758
|overall_frequency=0.0412716
|n_genomes=5
|n_genomes_annotated=0
|n_haplomes=7
|n_articles=1
|n_articles_annotated=1
|in_pharmgkb=Y
|nblosum100=8
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}