{{Rsnum
|rsid=2243380
|Gene=ROS1
|Chromosome=6
|position=117403216
|Orientation=plus
|GMAF=0.06152
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ROS1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 1.8 | 13.3 | 85.0
| HCB | 0.7 | 10.3 | 89.0
| JPT | 0.0 | 8.0 | 92.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 1.8 | 1.8 | 96.5
| CHB | 0.7 | 10.3 | 89.0
| CHD | 0.9 | 8.3 | 90.8
| GIH | 0.0 | 7.9 | 92.1
| LWK | 0.0 | 0.0 | 0.0
| MEX | 1.7 | 8.6 | 89.7
| MKK | 0.0 | 0.6 | 99.4
| TSI | 1.0 | 19.6 | 79.4
| HapMapRevision=28
}}{{Venter SNP
|rsid=2243380
|allele=T
|frequency=0.083
|uid=1103652977805
|type=heterozygous_SNP
|hugo=ROS1
|ensembl gene=ENSG00000047936
|ensembl transcript=ENST00000368508
|sift=AFFECT FUNCTION
|disease=A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM). An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
}}

{{GET Evidence
|gene=ROS1
|aa_change=Arg167Gln
|aa_change_short=R167Q
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2243380
|overall_frequency_n=728
|overall_frequency_d=10758
|overall_frequency=0.0676706
|n_genomes=6
|n_genomes_annotated=0
|n_haplomes=6
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.983
|nblosum100=0
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}