{{Rsnum
|rsid=2248663
|Gene=RNF219
|Chromosome=13
|position=78633453
|Orientation=minus
|GMAF=0.2328
|Gene_s=RNF219
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 88.5 | 9.7 | 1.8
| HCB | 49.3 | 36.8 | 14.0
| JPT | 49.1 | 41.1 | 9.8
| YRI | 31.3 | 51.7 | 17.0
| ASW | 43.9 | 47.4 | 8.8
| CHB | 49.3 | 36.8 | 14.0
| CHD | 47.7 | 44.0 | 8.3
| GIH | 72.3 | 25.7 | 2.0
| LWK | 49.1 | 39.1 | 11.8
| MEX | 53.4 | 36.2 | 10.3
| MKK | 51.9 | 37.8 | 10.3
| TSI | 84.3 | 14.7 | 1.0
| HapMapRevision=28
}}Having one or more copies of a C at rs2248663 in people without [[ApoE-ε4]] was linked to lower age of [[Alzheimer's disease]] onset and more plaques. {{PMID|23883936}} [http://blog.23andme.com/health-traits/new-study-helps-explain-alzheimers-genetic-risk/ 23andMe blog]

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}