{{Rsnum
|rsid=2249358
|Gene=KL
|Chromosome=13
|position=33049027
|Orientation=plus
|GMAF=0.3274
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=KL
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 51.6 | 39.1 | 9.4
| HCB | 44.4 | 53.3 | 2.2
| JPT | 56.8 | 43.2 | 0.0
| YRI | 21.3 | 47.5 | 31.1
| ASW | 0.0 | 0.0 | 0.0
| CHB | 44.4 | 53.3 | 2.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[rs2249358]] is one of 2 SNPs (the other is [[rs211239]]) in the [[KLOTHO]] gene found in a study of ~150 [[sickle cell anemia]] (SCA) patients to be associated with risk for [[priapism]]. The odds ratio is 2.6 (CI: 1.4-5.5) for carriers of a [[rs2249358]](G) allele, as in dbSNP orientation.{{PMID|15638863}}

{{omim
|desc=SICKLE CELL ANEMIA
|id=603903
|rsnum=2249358
}}

{{omim
|desc=KLOTHO; KL
|id=604824
|rsnum=2249358
}}

{{PMID Auto
|PMID=15784727
|Title=Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis.
|OA=1
}}

{{PMID Auto
|PMID=20401335
|Title=Sickle Cell Disease in the Post Genomic Era: A Monogenic Disease with a Polygenic Phenotype.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}