{{Rsnum
|rsid=225014
|Gene=DIO2
|Chromosome=14
|position=80203237
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.4206
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=DIO2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 15.9 | 46.0 | 38.1
| HCB | 22.6 | 48.2 | 29.2
| JPT | 22.1 | 44.2 | 33.6
| YRI | 18.6 | 51.0 | 30.3
| ASW | 24.6 | 54.4 | 21.1
| CHB | 22.6 | 48.2 | 29.2
| CHD | 23.1 | 50.9 | 25.9
| GIH | 25.7 | 45.5 | 28.7
| LWK | 36.4 | 43.6 | 20.0
| MEX | 27.6 | 46.6 | 25.9
| MKK | 35.3 | 46.2 | 18.6
| TSI | 10.8 | 47.1 | 42.2
| HapMapRevision=28
}}
{{PMID Auto
|PMID=19427350
|Title=Association of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population
}}

{{PMID Auto
|PMID=20178852
|Title=Association Study between Polymorphisms in Selenoprotein Genes and Susceptibility to Kashin-Beck Disease
}}

{{PMID Auto
|PMID=19352319
|Title=Novel insights into thyroid hormones from the study of common genetic variation
}}

{{PMID Auto
|PMID=19190113
|Title=Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients.
}}

{{PMID Auto
|PMID=18334578
|Title=Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis.
}}

{{PMID Auto
|PMID=20566590
|Title=Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis
}}

{{PMID Auto
|PMID=21715540
|Title=The Type 2 Deiodinase ORFa-Gly3Asp Polymorphism (rs12885300) Influences the Set Point of the Hypothalamus-Pituitary-Thyroid Axis in Patients Treated for Differentiated Thyroid Carcinoma
}}

{{PMID Auto
|PMID=22492780
|Title=Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues.
}}

{{PMID|15286152|OA=1
}} Positive association of the DIO2 (deiodinase type 2) gene with mental retardation in the iodine-deficient areas of China.

{{PMID|18492748|OA=1
}} A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine.

{{PMID|18815314|OA=1
}} Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.

{{PMID|20930717}} D2 Thr92Ala and PPARgamma2 Pro12Ala polymorphisms interact in the modulation of insulin resistance in type 2 diabetic patients.

{{PMID|21685153|OA=1
}} Type 2 deiodinase and host responses of sepsis and acute lung injury.

{{GET Evidence
|gene=DIO2
|aa_change=Thr92Ala
|aa_change_short=T92A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs225014
|overall_frequency_n=3944
|overall_frequency_d=10104
|overall_frequency=0.39034
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=3
|n_articles=0
|n_articles_annotated=0
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24058403
|Title=Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}