{{Rsnum
|rsid=2250417
|Gene=BCO2
|Chromosome=11
|position=112214593
|Orientation=minus
|GMAF=0.3407
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=BCO2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 24.1 | 47.3 | 28.6
| HCB | 81.3 | 16.4 | 2.2
| JPT | 71.7 | 26.5 | 1.8
| YRI | 59.9 | 33.3 | 6.8
| ASW | 49.1 | 40.4 | 10.5
| CHB | 81.3 | 16.4 | 2.2
| CHD | 71.3 | 27.8 | 0.9
| GIH | 50.5 | 44.6 | 5.0
| LWK | 73.4 | 22.0 | 4.6
| MEX | 29.3 | 50.0 | 20.7
| MKK | 67.3 | 30.1 | 2.6
| TSI | 34.3 | 48.0 | 17.6
| HapMapRevision=28
}}

{{PMID|18464913|OA=1
}} Interleukin 18 ([[IL18]]) protein levels

{{GWAS Summary
|SNP=rs2250417
|PubMedID=18464913
|Condition=Protein quantitative trait loci
|Gene=IL18
|Risk Allele=A
|pValue=7.00E-013
|OR=NA
|95CI=
|OA=1
}}

{{PharmGKB
|RSID=rs2250417
|Name_s=
|Gene_s=BCO2
|Feature=
|Evidence=PubMed ID:18464913; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs) (Initial Sample Size: 1,200 individuals; Replication Sample Size: NR; Risk Allele: rs2250417-A).
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356797
}}

{{PMID Auto
|PMID=18853133
|Title=Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19468064
|Title=Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2250417
|overall_frequency_n=43
|overall_frequency_d=128
|overall_frequency=0.335938
|n_genomes=32
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=24182552
  |Trait=Inflammatory biomarkers
  |Title=Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.
  |RiskAllele=T
  |Pval=2E-32
  |OR=.10
  |ORtxt=[0.08-0.12] unit increase
  }}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}