{{Rsnum
|rsid=2250889
|Gene=MMP9
|Chromosome=20
|position=46013767
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.1543
|Gene_s=MMP9,TRIM78P
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 90.8 | 9.2 | 0.0
| HCB | 51.1 | 42.2 | 6.7
| JPT | 45.5 | 45.5 | 9.1
| YRI | 69.8 | 30.2 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 51.1 | 42.2 | 6.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[rs2250889]], a SNP also known as P574R, is located in the [[MMP9]] gene.

In a study of 744 Chinese patients with incident lung cancer [[rs2250889]](C;G) heterozygotes and [[rs2250889]](C;C) homozygotes had 1.46-fold (CI: 0.94-2.26) and 1.69-fold elevated risk (CI: 1.10-2.60) for [[lung cancer]], respectively, compared with the (G;G) genotype. There was an additive effect of having additional [[MMP9]] risk alleles.{{PMID|16061858}}

{{PMID Auto
|PMID=19633731
|Title=Association of the single nucleotide polymorphisms in the extracellular matrix metalloprotease-9 gene with PACG in southern China
|OA=1
}}

{{PMID Auto
|PMID=20144500
|Title=Matrix metalloproteinase-9 polymorphism and risk of pelvic organ prolapse in Taiwanese women
}}

{{PMID Auto
|PMID=22113040
|Title=[Study on association between single nucleotide polymorphisms of MMP7, MMP8, MMP9 genes and development of gastric cancer and lymph node metastasis]
}}

{{PMID Auto
|PMID=22621753
|Title=Higher risk of matrix metalloproteinase (MMP-2, 7, 9) and tissue inhibitor of metalloproteinase (TIMP-2) genetic variants to gallbladder cancer
}}

{{PMID Auto
|PMID=22664146
|Title=Association of matrix metalloproteinases (MMP2, MMP7 and MMP9) genetic variants with left ventricular dysfunction in coronary artery disease patients
}}

{{PMID Auto
|PMID=15748780
|Title=Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease.
}}

{{PMID Auto
|PMID=17346338
|Title=Matrix Metalloproteinase-9 (MMP-9) polymorphisms in patients with cutaneous malignant melanoma.
|OA=1
}}

{{PMID Auto
|PMID=18191955
|Title=Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.
|OA=1
}}

{{PMID Auto
|PMID=18512818
|Title=Association of a nonsynonymous single-nucleotide polymorphism of matrix metalloproteinase 9 with giant cell arteritis.
}}

{{PMID Auto
|PMID=19064570
|Title=Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=20078883
|Title=Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population.
|OA=1
}}

{{GET Evidence
|gene=MMP9
|aa_change=Arg574Pro
|aa_change_short=R574P
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2250889
|overall_frequency_n=9875
|overall_frequency_d=10758
|overall_frequency=0.917922
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=85
|n_articles=0
|n_articles_annotated=0
|nblosum100=5
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=23955812
|Title=Functional polymorphisms of matrix metalloproteinase-9 and survival in patients with locoregionally advanced nasopharyngeal carcinoma treated with chemoradiotherapy
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}