{{Rsnum
|rsid=2251746
|Gene=FCER1A
|Chromosome=1
|position=159302270
|Orientation=plus
|GMAF=0.1492
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=FCER1A
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 5.3 | 45.1 | 49.6
| HCB | 0.0 | 6.6 | 93.4
| JPT | 0.0 | 8.8 | 91.2
| YRI | 0.0 | 6.2 | 93.8
| ASW | 0.0 | 19.3 | 80.7
| CHB | 0.0 | 6.6 | 93.4
| CHD | 0.0 | 7.3 | 92.7
| GIH | 13.0 | 26.0 | 61.0
| LWK | 0.0 | 11.0 | 89.0
| MEX | 1.7 | 15.5 | 82.8
| MKK | 2.6 | 30.5 | 66.9
| TSI | 6.9 | 35.3 | 57.8
| HapMapRevision=28
}}[[rs2251746]] is a SNP in the gene encoding the alpha chain of the high affinity receptor for IgE ([[FCER1A]]) on chromosome 1q23. High levels of serum IgE are associated with allergies, and are mediators of autoimmune diseases.

An examination of over 11,000 Germans led to the conclusion that [[rs2251746]] (and one other FCER1A SNP, the tightly linked [[rs2427837]]) were strongly associated with high levels of serum IgE. The more common (T) allele was associated with higher serum IgE, and the effect appeared to be additive. Therefore, homozygous [[rs2251746]](C;C) individuals may be at lower risk for atopic [[eczema]] and [[asthma]] than carriers of one or two (T) alleles. {{PMID|18846228|OA=1
}}

In Japanese patients, [[rs2251746]] may be a poor predictor, and the neighboring [[rs2427827]] may be more appropriate. {{PMID|20141544}}

{{GWAS Summary
|SNP=rs2251746
|PubMedID=18846228
|Condition=Serum IgE levels
|Gene=FCER1A
|Risk Allele=C
|pValue=2.00E-020
|OR=19.2
|95CI=NR) % decreas
|OA=1
}}

{{PharmGKB
|RSID=rs2251746
|Name_s=
|Gene_s=FCER1A
|Feature=
|Evidence=PubMed ID:18846228; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus (Initial Sample Size: 1,530 individuals; Replication Sample Size: 9,769 individuals; Risk Allele: rs2251746-C). This variant is associated with Serum IgE levels.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356542
}}

{{PMID Auto
|PMID=22222815
|Title=Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population
}}

{{PMID Auto GWAS
|PMID=22075330
|Trait=None
|Title=A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
|RiskAllele=C
|Pval=5E-26
|OR=0.0900
|ORtxt=None
|OA=1
}}

{{PMID|19245427}} Common variants in FCER1A influence total serum IgE levels from cord blood up to six years of life.

{{PMID|19474294|OA=1
}} Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

{{PMID|20141544}} FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients.

{{PMID|20369022|OA=1
}} Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2251746
|overall_frequency_n=22
|overall_frequency_d=128
|overall_frequency=0.171875
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23725541
|Title=Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics.
}}

{{PMID Auto
|PMID=25029546
|Title=A Disease Marker for Aspirin-Induced Chronic Urticaria
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}