{{Rsnum
|rsid=2259816
|Gene=HNF1A
|Chromosome=12
|position=120997784
|Orientation=minus
|GMAF=0.3669
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=HNF1A
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 12.4 | 51.3 | 36.3
| HCB | 19.7 | 55.5 | 24.8
| JPT | 35.4 | 53.1 | 11.5
| YRI | 1.4 | 14.3 | 84.4
| ASW | 1.8 | 31.6 | 66.7
| CHB | 19.7 | 55.5 | 24.8
| CHD | 21.1 | 46.8 | 32.1
| GIH | 26.7 | 41.6 | 31.7
| LWK | 2.8 | 29.4 | 67.9
| MEX | 14.0 | 38.6 | 47.4
| MKK | 6.4 | 46.2 | 47.4
| TSI | 15.7 | 50.0 | 34.3
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19198612
|Trait=Coronary artery disease
|Title=New susceptibility locus for coronary artery disease on chromosome 3q22.3
|RiskAllele=T
|Pval=5E-7
|OR=1.08
|ORtxt=[1.05-1.11]
|OA=1
}}

{{PharmGKB
|RSID=rs2259816
|Name_s=
|Gene_s=HNF1A
|Feature=
|Evidence=PubMed ID:19198612; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: New susceptibility locus for coronary artery disease on chromosome 3q22.3. (Initial Sample Size: 6,990 cases, 8,955 controls; Replication Sample Size: 12,417 cases, 12,411 controls); (Region: 12q24.31; Reported Gene(s): HNF1A,C12orf43; Risk Allele: rs2259816-T); (p-value= 0.0000005).This variant is associated with Coronary artery disease.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739957
}}

{{PMID Auto
|PMID=21062467
|Title=Effect of the rs2259816 polymorphism in the HNF1A gene on circulating levels of C-reactive protein and coronary artery disease (The Ludwigshafen Risk and Cardiovascular Health Study)
|OA=1
}}

{{PMID Auto
|PMID=18439552
|Title=Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
|OA=1
}}

{{PMID Auto
|PMID=19956433
|Title=Genetics of coronary artery disease: focus on genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=20835900
|Title=Genetics of diabetes complications.
|OA=1
}}

{{PMID Auto
|PMID=21811992
|Title=[Association of single nucleotide polymorphism on chromosome 12q24.31 with susceptibility to coronary artery disease].
}}

{{PMID Auto
|PMID=22152955
|Title=Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2259816
|overall_frequency_n=40
|overall_frequency_d=126
|overall_frequency=0.31746
|n_genomes=26
|n_genomes_annotated=0
|n_haplomes=34
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=22939635
  |Trait=C-reactive protein
  |Title=Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
  |RiskAllele=T
  |Pval=3E-10
  |OR=.14
  |ORtxt=[0.092-0.190] unit increase
  |OA=1
}}

{{PMID Auto
|PMID=24763700
|Title=New Variants Including ARG1 Polymorphisms Associated with C-Reactive Protein Levels Identified by Genome-Wide Association and Pathway Analysis
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}