{{Rsnum
|rsid=2266782
|Gene=FMO3
|Chromosome=1
|position=171107825
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.3531
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=FMO3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 19.6 | 44.6 | 35.7
| HCB | 5.8 | 28.5 | 65.7
| JPT | 5.3 | 31.0 | 63.7
| YRI | 22.4 | 51.7 | 25.9
| ASW | 24.6 | 43.9 | 31.6
| CHB | 5.8 | 28.5 | 65.7
| CHD | 4.6 | 34.9 | 60.6
| GIH | 12.9 | 35.6 | 51.5
| LWK | 40.4 | 43.1 | 16.5
| MEX | 15.5 | 36.2 | 48.3
| MKK | 23.7 | 42.9 | 33.3
| TSI | 8.8 | 50.0 | 41.2
| HapMapRevision=28
}}{{Venter SNP
|rsid=2266782
|allele=A
|frequency=0.383
|uid=1103675259919
|type=heterozygous_SNP
|hugo=FMO3
|ensembl gene=ENSG00000007933
|ensembl transcript=ENST00000367755
|sift=TOLERATED
|disease=Defects in FMO3 are the cause of trimethylaminuria (TMAuria) (MIM:602079); also known as fish-odor syndrome. TMAuria is an inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated N-oxidation of amino-trimethylamine (TMA) derived from foodstuffs. Such individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine.
}}

{{omim
|id=136132
|rsnum=2266782
|variant=0015
}}

{{ClinVar
|rsid=2266782
|Reversed=0
|FwdREF=G
|FwdALT=A
|REF=G
|ALT=A
|RSPOS=171107825
|CHROM=1
|GMAF=0.3535
|dbSNPBuildID=100
|SSR=0
|SAO=1
|VP=0x050378000a0517051f110100
|GENEINFO=FMO3:2328
|GENE_NAME=FMO3
|GENE_ID=2328
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.171107825G>A
|CLNSRC=ClinVar; GeneReviews; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSIG=255
|CLNCUI=C0342739
|CLNDBN=Trimethylaminuria, mild; Trimethylaminuria
|Disease=Trimethylaminuria
|CLNACC=RCV000017711.1; RCV000020653.1
|Tags=PM;TPA;PMC;S3D;SLO;NSM;REF;ASP;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.6469; 0.3531
|CLNDSDB=GeneReviews:MedGen:OMIM:SNOMED_CT
|CLNDSDBID=NBK1103:C0342739:602079:237959005
|CLNSRCID=NM_001002294.2:c.472G>A; NBK1103; 136132.0015
|COMMON=1
}}

{{PMID Auto
|PMID=15858076
|Title=Discovery of novel flavin-containing monooxygenase 3 (FMO3) single nucleotide polymorphisms and functional analysis of upstream haplotype variants.
|OA=1
}}

{{PMID Auto
|PMID=18180394
|Title=Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans.
|OA=1
}}

{{PMID Auto
|PMID=18565990
|Title=Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=20056567
|Title=Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.
|OA=1
}}

{{PMID Auto
|PMID=9536088
|Title=Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication.
}}

{{PMID Auto
|PMID=10485731
|Title=Mild trimethylaminuria caused by common variants in FMO3 gene.
}}

{{GET Evidence
|gene=FMO3
|aa_change=Glu158Lys
|aa_change_short=E158K
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2266782
|overall_frequency_n=4613
|overall_frequency_d=10758
|overall_frequency=0.428797
|n_genomes=43
|n_genomes_annotated=0
|n_haplomes=51
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=3
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=0
|autoscore=3
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23390647
|Title=[Catalase gene polymorphism is associated with increased risk of cerebral stroke in hypertensive patients]
}}

{{PMID Auto
|PMID=24165757
|Title=The association of cytochrome P450 genetic polymorphisms with sulfolane formation and the efficacy of a busulfan-based conditioning regimen in pediatric patients undergoing hematopoietic stem cell transplantation
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}