{{Rsnum
|rsid=2268983
|Gene=ACTN1
|Chromosome=14
|position=68941980
|Orientation=minus
|GMAF=0.3361
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=ACTN1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 27.4 | 51.3 | 21.2
| HCB | 7.3 | 38.0 | 54.7
| JPT | 1.8 | 29.2 | 69.0
| YRI | 1.4 | 22.4 | 76.2
| ASW | 0.0 | 42.1 | 57.9
| CHB | 7.3 | 38.0 | 54.7
| CHD | 6.4 | 37.6 | 56.0
| GIH | 7.9 | 41.6 | 50.5
| LWK | 1.8 | 26.4 | 71.8
| MEX | 17.2 | 50.0 | 32.8
| MKK | 5.8 | 39.4 | 54.8
| TSI | 38.6 | 46.5 | 14.9
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19247474
|Trait=Smoking behaviors
|Title=Genome-wide and candidate gene association study of cigarette smoking behaviors
|RiskAllele=
|Pval=0.000007
|OR=1.52
|ORtxt=[NR]
|OA=1
}}

{{PharmGKB
|RSID=rs2268983
|Name_s=
|Gene_s=ACTN1
|Feature=
|Evidence=PubMed ID:19247474; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide and candidate gene association study of cigarette Smoking behaviors. (Initial Sample Size: 4,611 individuals (2,617 smokers); Replication Sample Size: NR); (Region: 14q24.1; Reported Gene(s): ACTN1; Risk Allele: rs2268983-?); (p-value= 0.000007).This variant is associated with Smoking behaviors.
|Drugs=
|Drug Classes=
|Diseases=Tobacco Use Disorder
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739939
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2268983
|overall_frequency_n=64
|overall_frequency_d=112
|overall_frequency=0.571429
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=58
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22719919
|Title=Glutamate and synaptic plasticity systems and smoking behavior: results from a genetic association study
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}