{{Rsnum
|rsid=2269475
|Gene=AIF1
|Chromosome=6
|position=31616154
|Orientation=minus
|GMAF=0.1602
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=AIF1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 2.7 | 26.5 | 70.8
| HCB | 1.5 | 29.2 | 69.3
| JPT | 8.0 | 33.6 | 58.4
| YRI | 0.0 | 12.9 | 87.1
| ASW | 3.5 | 26.3 | 70.2
| CHB | 1.5 | 29.2 | 69.3
| CHD | 4.6 | 17.4 | 78.0
| GIH | 1.0 | 16.8 | 82.2
| LWK | 1.8 | 10.9 | 87.3
| MEX | 1.7 | 22.4 | 75.9
| MKK | 1.9 | 16.0 | 82.1
| TSI | 0.0 | 18.6 | 81.4
| HapMapRevision=28
}}[[rs2269475]] is a SNP in the allograft inflammatory factor-1 (AIF-1) gene, which may be involved in inflammatory processes.

In a study of 276 Polish Caucasian patients with [[rheumatoid arthritis]], the frequency of [[rs2269475]](A) carriers among patients was 31.9% vs 19.1% among controls (p = 0.0003). The frequency of individuals positive for anti-cyclic citrullinated peptide (anti-CCP) antibodies was also significantly elevated in these carriers (odds ratio 8.82, CI: 2.06-37.7).{{PMID|18721278}}

{{PMID|17498268}} Allograft inflammatory factor-1 and tumor necrosis factor single nucleotide polymorphisms in systemic sclerosis.

{{PMID|17522098}} An allograft inflammatory factor 1 (AIF1) single nucleotide polymorphism (SNP) is associated with anticentromere antibody positive systemic sclerosis.

{{PMID Auto
|PMID=23777936
|Title=Influence of Cyclooxygenase-2 (COX-2) gene promoter-1195 and allograft inflammatory factor-1 (AIF-1) polymorphisms on allograft outcome in Hispanic kidney transplant recipients.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}