{{Rsnum
|rsid=2270641
|Gene=SLC18A1
|Chromosome=8
|position=20180955
|Orientation=plus
|GMAF=0.2732
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=SLC18A1
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 13.3 | 48.7 | 38.1
| HCB | 8.0 | 33.6 | 58.4
| JPT | 13.3 | 43.4 | 43.4
| YRI | 0.7 | 19.7 | 79.6
| ASW | 1.8 | 29.8 | 68.4
| CHB | 8.0 | 33.6 | 58.4
| CHD | 7.4 | 27.8 | 64.8
| GIH | 10.9 | 34.7 | 54.5
| LWK | 1.8 | 20.9 | 77.3
| MEX | 12.3 | 28.1 | 59.6
| MKK | 3.9 | 30.3 | 65.8
| TSI | 13.7 | 50.0 | 36.3
| HapMapRevision=28
}}[[rs2270641]] is a SNP in the vesicular monoamine transporter [[SLC18A1]] gene, encoding a Thr4Pro substitution. In dbSNP orientation, the (G) allele is associated with the Proline.

A study of 62 patients with [[schizophrenia]] concluded that the frequency of [[rs2270641]](G;G) homozygotes was significantly higher. The reported odds ratio was 3.74 (CI: 1.7-8.2, p=0.0006) in this population of European descent.{{PMID|18451639}}

Note: another SNP, [[rs56575139]], marks the same genomic location as [[rs2270641]].

{{PMID Auto
|PMID=16936705
|Title=Variations in the vesicular monoamine transporter 1 gene (VMAT1/SLC18A1) are associated with bipolar i disorder.
|OA=1
}}

{{PMID Auto
|PMID=17134514
|Title=Association study of the vesicular monoamine transporter 1 (VMAT1) gene with schizophrenia in a Japanese population.
|OA=1
}}

{{PMID Auto
|PMID=19911060
|Title=Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
|OA=1
}}

{{GET Evidence
|gene=SLC18A1
|aa_change=Thr4Pro
|aa_change_short=T4P
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2270641
|overall_frequency_n=3055
|overall_frequency_d=10744
|overall_frequency=0.284345
|n_genomes=33
|n_genomes_annotated=0
|n_haplomes=37
|n_articles=0
|n_articles_annotated=0
|nblosum100=4
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}