{{Rsnum
|rsid=2271293
|Gene=NUTF2
|Chromosome=16
|position=67868167
|Orientation=plus
|GMAF=0.09091
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=NUTF2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 1.8 | 15.0 | 83.2
| HCB | 0.0 | 3.6 | 96.4
| JPT | 0.0 | 8.0 | 92.0
| YRI | 0.0 | 15.8 | 84.2
| ASW | 1.8 | 10.5 | 87.7
| CHB | 0.0 | 3.6 | 96.4
| CHD | 0.0 | 9.2 | 90.8
| GIH | 1.0 | 20.8 | 78.2
| LWK | 0.0 | 6.4 | 93.6
| MEX | 3.6 | 19.6 | 76.8
| MKK | 0.0 | 3.2 | 96.8
| TSI | 3.9 | 20.6 | 75.5
| HapMapRevision=28
}}per the [http://blog.23andme.com/2008/12/08/new-papers-from-nature-genetics-yield-a-bounty-of-cholesterol-snps/ 23andMe blog], the minor allele of this SNP (A) was associated with decreased [[LDL cholesterol]], increased HDL, and decreased [[triglycerides]]
 
{| border="1"
|-
!SNP
!Rarer allele
!LDL
!HDL
!TG
|-
| [[rs6544713]] || T || + || ||
|-
| [[rs2650000]] || A || + || ||
|-
| [[rs471364]] || C || || - ||
|-
| [[rs1800961]] || T || || - ||
|-
| [[rs7679]] || C || || - || +
|-
| [[rs2967605]] || T || || - ||
|-
| [[rs2409722]] || T || || || -
|-
| [[rs10903129]] || A || - || - || -
|-
| [[rs6756629]] || A || - || + || -
|-
| [[rs12670798]] || C || + || + || +
|-
| [[rs7395662]] || A || - || + || +
|-
| [[rs174570]] || T || - || - || +
|-
| [[rs2271293]] || A || - || + || -
|-
| [[rs2624265]] || C || || || +
|-
| [[rs2167079]] || T || || + ||
|-
| [[rs9891572]] || T || || + ||
|-
| [[rs4844614]] || T || + || ||
|-
| [[rs5031002]] || G || + || ||
|-
|}

{{PMID Auto GWAS
|PMID=19060911
|Trait=HDL cholesterol
|Title=Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
|RiskAllele=G
|Pval=8E-16
|OR=0.13
|ORtxt=[NR] SD decrease
|OA=1
}}
{{PMID Auto GWAS
|PMID=19060906
|Trait=HDL cholesterol
|Title=Common variants at 30 loci contribute to polygenic dyslipidemia
|RiskAllele=A
|Pval=9E-13
|OR=0.07
|ORtxt=[0.01-0.13] SD increase
|OA=1
}}

{{PharmGKB
|RSID=rs2271293
|Name_s=
|Gene_s=NUTF2, EDC4
|Feature=
|Evidence=PubMed ID:19060906; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variants at 30 loci contribute to polygenic dyslipidemia. (Initial Sample Size: 19,840 individuals; Replication Sample Size: Up to 20,623 individuals); (Region: 16q22.1; Reported Gene(s): LCAT; Risk Allele: rs2271293-A); (p-value= 0.0000000000009).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740247
}}

{{PharmGKB
|RSID=rs2271293
|Name_s=
|Gene_s=NUTF2, EDC4
|Feature=
|Evidence=PubMed ID:19060911; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. (Initial Sample Size: 21,412 individuals; Replication Sample Size: NR); (Region: 16q22.1; Reported Gene(s): CTCF, PRMT8; Risk Allele: rs2271293-G); (p-value= 0.0000000000000008).This variant is associated with HDL cholesterol.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740204
}}

{{omim
|id=607687
|rsnum=2271293
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19951432
|Title=Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.
|OA=1
}}

{{PMID Auto
|PMID=20160193
|Title=Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.
|OA=1
}}

{{PMID Auto
|PMID=20385826
|Title=Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|OA=1
}}

{{PMID Auto
|PMID=20502693
|Title=Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2271293
|overall_frequency_n=13
|overall_frequency_d=128
|overall_frequency=0.101562
|n_genomes=9
|n_genomes_annotated=0
|n_haplomes=10
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}