{{Rsnum
|rsid=2273535
|Gene=AURKA
|Chromosome=20
|position=56386485
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=A
|GMAF=0.3163
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=AURKA
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 69.2 | 26.2 | 4.6
| HCB | 13.3 | 46.7 | 40.0
| JPT | 9.1 | 56.8 | 34.1
| YRI | 68.3 | 27.0 | 4.8
| ASW | 0.0 | 0.0 | 0.0
| CHB | 13.3 | 46.7 | 40.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
SNP [[rs2273535]], also known as F31I or Phe31Ile, has been associated with increased risk for several cancers, in most cases when individuals are homozgyous for the risk allele, [[rs2273535(T)]], as oriented to the dbSNP entry.

A meta-analysis of almost 10,000 cases of breast, colon, ovarian, prostate, lung, esophageal and non-melanoma skin [[cancer]], compared to an equal number of Caucasian controls, determined the following risks (i.e., odds ratios, OR) {{PMID|15802297}}:

*For [[colorectal cancer]]: OR for homozygotes of 1.5 (CI: 1.14-1.99)
*For [[breast cancer]]: OR for homozygotes of 1.35 (CI: 1.12-1.64)
*For any of the cancer types studied: OR for heterozygotes of 1.10 (CI: 1.03-1.18), OR for homozygotes of 1.40 (CI: 1.22-1.59)

In a Chinese population, breast cancer risk for [[rs2273535(T;T)]] homozygotes compared to the other two genotypes led to an odds ratio of 1.66 (CI: 1.29-2.12), and appeared to be more pronounced for younger patients. {{PMID|15271856}}

However, for [[lung cancer]] (among Caucasians), [[rs2273535(T;T)]] homozygotes have been reported to be at lower risk; specifically, an odds ratio of 0.63 (CI: 0.41-0.96) has been reported. {{PMID|16926177}}
{{ neighbor
| rsid = 1047972
| distance = 78
}}

{{PMID|18431743|OA=1
}}  showed '''no association''' with ovarian cancer risk 4,624 invasive epithelial ovarian cancer cases and 8,113 controls of white non-Hispanic origin [[ovarian cancer]]

{{omim
|id=603072
|rsnum=2273535
|variant=0001
}}

{{PMID Auto
|PMID=21598251
|Title=Genetic polymorphisms in AURKA and BRCA1 are associated with breast cancer susceptibility in a Chinese Han population
}}

{{PMID Auto
|PMID=21630024
|Title=Single nucleotide polymorphisms in the 20q13 amplicon genes in relation to breast cancer risk and clinical outcome
}}

{{PMID Auto
|PMID=21050672
|Title=Genetic variants of NPAT-ATM and AURKA are associated with an early adverse reaction in the gastrointestinal tract of patients with cervical cancer treated with pelvic radiation therapy
}}

{{ClinVar
|rsid=2273535
|Reversed=0
|FwdREF=A
|FwdALT=T
|REF=A
|ALT=T
|RSPOS=54961541
|CHROM=20
|GMAF=0.3159
|dbSNPBuildID=100
|SSR=0
|SAO=1
|VP=0x05016800000017051f110101
|GENEINFO=AURKA:6790
|GENE_NAME=AURKA
|GENE_ID=6790
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000020.10:g.54961541A>T
|CLNORIGIN=0
|CLNSIG=255
|Tags=PM;PMC;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.6837; 0.3163
|CLNACC=RCV000007021.1
|CLNDBN=Colon cancer, susceptibility to
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=603072.0001
|COMMON=1
|Disease=Colon cancer
}}

{{PMID Auto
|PMID=16465622
|Title=Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes.
|OA=1
}}

{{PMID Auto
|PMID=17505013
|Title=Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians.
|OA=1
}}

{{PMID Auto
|PMID=18802780
|Title=Common genetic polymorphisms of AURKA and prostate cancer risk.
}}

{{PMID Auto
|PMID=18854777
|Title=Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.
|OA=1
}}

{{PMID Auto
|PMID=19551141
|Title=Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.
|OA=1
}}

{{PMID Auto
|PMID=20922573
|Title=Functional polymorphisms associated with disease-free survival in resected carcinoma of the esophagus.
|OA=1
}}

{{GET Evidence
|gene=AURKA
|aa_change=Phe31Ile
|aa_change_short=F31I
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2273535
|overall_frequency_n=2018
|overall_frequency_d=10758
|overall_frequency=0.187581
|n_genomes=22
|n_genomes_annotated=0
|n_haplomes=28
|n_articles=2
|n_articles_annotated=2
|qualityscore_case_control=4
|qualitycomment_case_control=Y
|in_omim=Y
|nblosum100=2
|autoscore=2
|webscore=N
|summary_short=The AURKA (STK15) 91T->A variant is preferentially amplified and linked to the degree of aneuploidy in colon tumors. The variant is a low-penetrance cancer susceptibility allele associated with multiple cancer types.
}}

{{PMID Auto
|PMID=24252226
|Title=STK15 rs2273535 polymorphism and cancer risk: A meta-analysis of 74,896 subjects
}}

{{PMID Auto
|PMID=25253995
|Title=Association between genetic polymorphisms in AURKA (rs2273535 and rs1047972) and breast cancer risk: a meta-analysis involving 37,221 subjects
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}