{{Rsnum
|rsid=2274089
|Gene=LRRC16A
|Chromosome=6
|position=25488355
|Orientation=minus
|GMAF=0.04362
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=LRRC16A
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 15.2 | 83.9
| HCB | 0.0 | 7.6 | 92.4
| JPT | 0.0 | 4.6 | 95.4
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 3.6 | 96.4
| CHB | 0.0 | 7.6 | 92.4
| CHD | 0.0 | 11.1 | 88.9
| GIH | 0.0 | 2.0 | 98.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 1.8 | 10.7 | 87.5
| MKK | 0.0 | 0.7 | 99.3
| TSI | 1.0 | 9.0 | 90.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19084217
|Trait=Serum markers of iron status
|Title=Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels
|RiskAllele=
|Pval=3E-7
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PharmGKB
|RSID=rs2274089
|Name_s=
|Gene_s=LRRC16A
|Feature=
|Evidence=PubMed ID:19084217; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (Initial Sample Size: 459 twin pairs; Replication Sample Size: NR); (Region: 6p22.2; Reported Gene(s): LRRC16; Risk Allele: rs2274089-?); (p-value= 0.0000003).This variant is associated with Serum markers of iron status(serum transferrin).
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740109
}}

{{PharmGKB
|RSID=rs2274089
|Name_s=
|Gene_s=LRRC16A
|Feature=
|Evidence=PubMed ID:19084217; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (Initial Sample Size: 459 twin pairs; Replication Sample Size: NR); (Region: 6p22.2; Reported Gene(s): LRRC16; Risk Allele: rs2274089-?); (p-value= 0.0000008).This variant is associated with Serum markers of iron status(transferrin saturation).
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740121
}}

{{PharmGKB
|RSID=rs2274089
|Name_s=
|Gene_s=LRRC16A
|Feature=
|Evidence=PubMed ID:19084217; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels. (Initial Sample Size: 459 twin pairs; Replication Sample Size: NR); (Region: 6p22.2; Reported Gene(s): LRRC16A; Risk Allele: rs2274089-?); (p-value= 0.000005).This variant is associated with Serum markers of iron status(serum iron).
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740126
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2274089
|overall_frequency_n=6
|overall_frequency_d=128
|overall_frequency=0.046875
|n_genomes=3
|n_genomes_annotated=0
|n_haplomes=3
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
|n_web_uneval=10
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}