{{Rsnum
|rsid=2274158
|Gene=DFNB31
|Chromosome=9
|position=114403926
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=A
|GMAF=0.2351
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=DFNB31
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 58.6 | 36.9 | 4.5
| HCB | 45.6 | 42.6 | 11.8
| JPT | 30.1 | 50.4 | 19.5
| YRI | 91.8 | 8.2 | 0.0
| ASW | 89.5 | 8.8 | 1.8
| CHB | 45.6 | 42.6 | 11.8
| CHD | 47.2 | 38.9 | 13.9
| GIH | 56.0 | 38.0 | 6.0
| LWK | 90.0 | 9.1 | 0.9
| MEX | 48.3 | 39.7 | 12.1
| MKK | 86.5 | 13.5 | 0.0
| TSI | 65.7 | 31.4 | 2.9
| HapMapRevision=28
}}{{Venter SNP
|rsid=2274158
|allele=T
|frequency=0.3
|uid=1103652166703
|type=heterozygous_SNP
|hugo=DFNB31
|ensembl gene=ENSG00000095397
|ensembl transcript=ENST00000362057
|sift=
|disease=Defects in WHRN are a cause of autosomal recessive deafness type 31 (DFNB31) (MIM:607084). This sensorineural hearing loss is bilateral and profound and manifests itself already in the prelingual period in early childhood.
}}

{{ neighbor
| rsid = 2274159
| distance = 40
}}

{{ClinVar
|rsid=2274158
|Reversed=0
|FwdREF=G
|FwdALT=T
|REF=G
|ALT=T
|RSPOS=117166206
|CHROM=9
|GMAF=0.2344
|dbSNPBuildID=100
|SSR=0
|SAO=1
|VP=0x05016800000015051f100101
|GENEINFO=DFNB31:25861
|GENE_NAME=DFNB31
|GENE_ID=25861
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000009.11:g.117166206G>T
|CLNORIGIN=1
|CLNSIG=2
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD
|CAF=0.7649; 0.2351
|CLNACC=RCV000038892.1
|CLNDBN=AllHighlyPenetrant
|CLNDSDB=MedGen
|CLNDSDBID=CN169374
|COMMON=1
|Disease=AllHighlyPenetrant
}}

{{PMID Auto
|PMID=20352026
|Title=Sequence variants of the DFNB31 gene among Usher syndrome patients of diverse origin.
|OA=1
}}

{{GET Evidence
|gene=DFNB31
|aa_change=Asn796Lys
|aa_change_short=N796K
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2274158
|overall_frequency_n=1950
|overall_frequency_d=10758
|overall_frequency=0.18126
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=22
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=1
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}