{{Rsnum
|rsid=2274159
|Gene=DFNB31
|Chromosome=9
|position=114403966
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.4219
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=DFNB31
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 24.8 | 48.7 | 26.5
| HCB | 30.7 | 47.4 | 21.9
| JPT | 14.2 | 46.0 | 39.8
| YRI | 64.6 | 34.0 | 1.4
| ASW | 61.4 | 33.3 | 5.3
| CHB | 30.7 | 47.4 | 21.9
| CHD | 31.2 | 46.8 | 22.0
| GIH | 25.7 | 42.6 | 31.7
| LWK | 69.1 | 30.0 | 0.9
| MEX | 27.6 | 46.6 | 25.9
| MKK | 46.2 | 42.9 | 10.9
| TSI | 24.5 | 56.9 | 18.6
| HapMapRevision=28
}}{{Venter SNP
|rsid=2274159
|allele=G
|frequency=0.483
|uid=1103652166704
|type=heterozygous_SNP
|hugo=DFNB31
|ensembl gene=ENSG00000095397
|ensembl transcript=ENST00000362057
|sift=TOLERATED
|disease=Defects in WHRN are a cause of autosomal recessive deafness type 31 (DFNB31) (MIM:607084). This sensorineural hearing loss is bilateral and profound and manifests itself already in the prelingual period in early childhood.
}}

{{ neighbor
| rsid = 2274158
| distance = 40
}}
{{ neighbor
| rsid = 6478078
| distance = 92
}}

{{PMID Auto
|PMID=21239504
|Title=Novel Chemosensitive Single-Nucleotide Polymorphism Markers to Targeted Regimens in Metastatic Colorectal Cancer
}}

{{ClinVar
|rsid=2274159
|Reversed=0
|FwdREF=A
|FwdALT=G
|REF=A
|ALT=G
|RSPOS=117166246
|CHROM=9
|GMAF=0.4208
|dbSNPBuildID=100
|SSR=0
|SAO=1
|VP=0x05016800000017051f100100
|GENEINFO=DFNB31:25861
|GENE_NAME=DFNB31
|GENE_ID=25861
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000009.11:g.117166246A>G
|CLNORIGIN=1
|CLNSIG=2
|Tags=PM;PMC;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD
|CAF=0.5781; 0.4219
|CLNACC=RCV000038890.1
|CLNDBN=AllHighlyPenetrant
|CLNDSDB=MedGen
|CLNDSDBID=CN169374
|COMMON=1
|Disease=AllHighlyPenetrant
}}

{{PMID Auto
|PMID=20352026
|Title=Sequence variants of the DFNB31 gene among Usher syndrome patients of diverse origin.
|OA=1
}}

{{PMID Auto
|PMID=15841483
|Title=Identification of a novel frameshift mutation in the DFNB31/WHRN gene in a Tunisian consanguineous family with hereditary non-syndromic recessive hearing loss.
}}

{{GET Evidence
|gene=DFNB31
|aa_change=Val783Ala
|aa_change_short=V783A
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2274159
|overall_frequency_n=4433
|overall_frequency_d=10758
|overall_frequency=0.412065
|n_genomes=39
|n_genomes_annotated=0
|n_haplomes=50
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=2
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}