{{Rsnum
|rsid=2274924
|Gene=TRPM6
|Chromosome=9
|position=74761731
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.2489
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TRPM6
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 69.0 | 29.2 | 1.8
| HCB | 51.1 | 43.8 | 5.1
| JPT | 46.0 | 44.2 | 9.7
| YRI | 34.2 | 45.9 | 19.9
| ASW | 43.9 | 52.6 | 3.5
| CHB | 51.1 | 43.8 | 5.1
| CHD | 43.1 | 44.0 | 12.8
| GIH | 49.5 | 41.6 | 8.9
| LWK | 37.3 | 45.5 | 17.3
| MEX | 86.2 | 13.8 | 0.0
| MKK | 55.8 | 36.5 | 7.7
| TSI | 70.6 | 29.4 | 0.0
| HapMapRevision=28
}}{{PMID|19149903|OA=1
}} 4.9x risk of [[type-2 diabetes]] among women carriers of both the rare alleles at [[rs3750425]] and [[rs2274924]] when their magnesium intake was lower than 250 mg per day.

{{GET Evidence
|gene=TRPM6
|aa_change=Lys1584Glu
|aa_change_short=K1584E
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2274924
|overall_frequency_n=2555
|overall_frequency_d=10758
|overall_frequency=0.237498
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=27
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.854
|genetests_testable=Y
|nblosum100=0
|autoscore=3
|n_web_uneval=6
}}

{{PMID Auto
|PMID=23343670
|Title=Higher Magnesium Intake Is Associated with Lower Fasting Glucose and Insulin, with No Evidence of Interaction with Select Genetic Loci, in a Meta-Analysis of 15 CHARGE Consortium Studies
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}