{{Rsnum
|rsid=227584
|Gene=C17orf53
|Chromosome=17
|position=44148179
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=C
|GMAF=0.4256
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=C17orf53
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 12.4 | 43.4 | 44.2
| HCB | 65.7 | 29.2 | 5.1
| JPT | 53.1 | 39.8 | 7.1
| YRI | 89.7 | 10.3 | 0.0
| ASW | 66.7 | 29.8 | 3.5
| CHB | 65.7 | 29.2 | 5.1
| CHD | 56.0 | 40.4 | 3.7
| GIH | 12.9 | 47.5 | 39.6
| LWK | 83.5 | 16.5 | 0.0
| MEX | 13.8 | 51.7 | 34.5
| MKK | 66.0 | 29.5 | 4.5
| TSI | 3.0 | 44.6 | 52.5
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19079262
|Trait=Bone mineral density (hip)
|Title=New sequence variants associated with bone mineral density
|RiskAllele=T
|Pval=9E-7
|OR=0.07
|ORtxt=[0.04-0.10] SD decrease
}}

{{PharmGKB
|RSID=rs227584
|Name_s=
|Gene_s=C17orf53
|Feature=
|Evidence=PubMed ID:19079262; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: New sequence variants associated with bone mineral density. (Initial Sample Size: 6,865 individuals; Replication Sample Size: 8,510 individuals); (Region: 17q21.31; Reported Gene(s): C17orf53; Risk Allele: rs227584-T); (p-value= 0.0000009).This variant is associated with Bone mineral density (hip).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740131
}}

{{PMID Auto
|PMID=19801982
|Title=Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
|OA=1
}}

{{PMID Auto GWAS
|PMID=22504420
|Trait=None
|Title=Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
|RiskAllele=A
|Pval=3E-24
|OR=0.0600
|ORtxt=None
|OA=1
}}

{{GET Evidence
|gene=C17ORF53
|aa_change=Thr126Pro
|aa_change_short=T126P
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs227584
|overall_frequency_n=5111
|overall_frequency_d=10758
|overall_frequency=0.475088
|n_genomes=42
|n_genomes_annotated=0
|n_haplomes=70
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|nblosum100=4
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}