{{Rsnum
|rsid=2275913
|Gene=IL17A
|Chromosome=6
|position=52186235
|Orientation=plus
|GMAF=0.315
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IL17A
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 12.4 | 46.0 | 41.6
| HCB | 24.1 | 48.2 | 27.7
| JPT | 18.6 | 49.6 | 31.9
| YRI | 0.0 | 12.2 | 87.8
| ASW | 1.8 | 21.1 | 77.2
| CHB | 24.1 | 48.2 | 27.7
| CHD | 31.2 | 46.8 | 22.0
| GIH | 18.8 | 41.6 | 39.6
| LWK | 0.0 | 10.0 | 90.0
| MEX | 1.7 | 53.4 | 44.8
| MKK | 1.3 | 9.0 | 89.7
| TSI | 15.7 | 45.1 | 39.2
| HapMapRevision=28
}}
[[rs2275913]], also known as G-197A, is a SNP in the [[IL17A]] gene.

A study of 811 Japanese subjects (524 without gastric cancer and 287 with gastric cancer) reported an odds ratio of 1.42 (CI: 1.09-1.85, p=0.01) for the [[rs2275913]](A) allele, and 3.02 (CI: 1.86-4.91, p<0.0001) for the (A;A) genotype, with [[gastric cancer]].{{PMID|19414056}}

{{PMID Auto
|PMID=19724898
|Title=Effect of polymorphisms of IL-17A, -17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa
}}

{{PMID Auto
|PMID=20437253
|Title=The Polymorphism of IL-17 G-152A was Associated with Childhood Asthma and Bacterial Colonization of the Hypopharynx in Bronchiolitis
}}

This "A"-allele of this SNP is also functionally associated with acute Graft-Versus-Host Disease after unrelated bone marrow transplantation {{doi|10.1371/journal.pone.0026229}}

{{PMID Auto
|PMID=22028838
|Title=A Genetic Variant in the IL-17 Promoter Is Functionally Associated with Acute Graft-Versus-Host Disease after Unrelated Bone Marrow Transplantation
|OA=1
}}

{{PMID Auto
|PMID=22118860
|Title=Interleukin 17 gene polymorphism is associated with anti-aquaporin 4 antibody-positive neuromyelitis optica in the Southern Han Chinese - A case control study
}}

{{PMID Auto
|PMID=22483685
|Title=Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population
}}

{{PMID Auto
|PMID=22461912
|Title=Association Analysis of IL-17A and IL-17F Polymorphisms in Chinese Han Women with Breast Cancer
|OA=1
}}

{{PMID Auto
|PMID=17828618
|Title=The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis.
}}

{{PMID Auto
|PMID=19208686
|Title=Association analysis of the interleukin 17A gene in Caucasian rheumatoid arthritis patients from Norway and New Zealand.
}}

{{PMID Auto
|PMID=19235914
|Title=Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=20620187
|Title=Interleukin-17 gene polymorphism is associated with Vogt-Koyanagi-Harada syndrome but not with Behcet's disease in a Chinese Han population.
}}

{{PMID Auto
|PMID=21217785
|Title=A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT.
}}

{{PMID Auto
|PMID=22692973
|Title=Interleukin-17 gene polymorphisms are associated with bladder cancer in a Chinese Han population.
}}

{{PMID Auto
|PMID=23049595
|Title=Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women
|OA=1
}}

{{PMID Auto
|PMID=23131423
|Title=Interleukin-17A genetic variants can confer resistance to brucellosis in Iranian population
}}

{{PMID Auto
|PMID=23376081
|Title=Analysis of IL-17 gene polymorphisms in Chinese patients with dilated cardiomyopathy
}}

{{PMID Auto
|PMID=23652560
|Title=Genetic polymorphisms of interleukin 17A and interleukin 17F and their association with inflammatory bowel disease in a Chinese Han population
}}

{{PMID Auto
|PMID=23137879
|Title=Evaluation of IL17A expression and of IL17A, IL17F and IL23R gene polymorphisms in Brazilian individuals with periodontitis
}}

{{PMID Auto
|PMID=23485736
|Title=Polymorphisms in immune/inflammatory cytokine genes are related to Parkinson's disease with cognitive impairment in the Han Chinese population
}}

{{PMID Auto
|PMID=24315816
|Title=Effect of interleukin-17A and interleukin-17F gene polymorphisms on the risk of gastric cancer in a Chinese population
}}

{{PMID Auto
|PMID=22537748
|Title=Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer.
}}

{{PMID Auto
|PMID=22559912
|Title=Increased activity of interleukin-23/interleukin-17 cytokine axis in primary antiphospholipid syndrome.
}}

{{PMID Auto
|PMID=22816799
|Title=Association of interleukin-17A and -17F gene single-nucleotide polymorphisms with autoimmune thyroid diseases.
}}

{{PMID Auto
|PMID=22955700
|Title=Influence of IL17A polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis.
}}

{{PMID Auto
|PMID=23219503
|Title=The IL-17F sequence variant is associated with susceptibility to tuberculosis.
}}

{{PMID Auto
|PMID=23280722
|Title=IL17A gene polymorphisms, serum IL-17A and IgE levels, and hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection.
}}

{{PMID Auto
|PMID=23778030
|Title=The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain.
}}

{{PMID Auto
|PMID=24857622
|Title=IL-17F but not IL-17A gene polymorphism confers risk to multiple sclerosis in a Chinese Han population
}}

{{PMID Auto
|PMID=24919468
|Title=Influence of the IL17A locus in giant cell arteritis susceptibility
}}

{{PMID Auto
|PMID=25012243
|Title=IL-17 gene polymorphism is associated with susceptibility to gastric cancer
}}

{{PMID Auto
|PMID=25227691
|Title=Association of IL-17A and IL-17 F gene polymorphisms with recurrent pregnancy loss in Iranian women
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}
{{on chip | NatGeo2}}