{{Rsnum
|rsid=227731
|Chromosome=17
|position=56695877
|Orientation=minus
|GMAF=0.4876
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 22.1 | 54.0 | 23.9
| HCB | 43.8 | 48.2 | 8.0
| JPT | 40.7 | 51.3 | 8.0
| YRI | 2.0 | 27.9 | 70.1
| ASW | 8.8 | 52.6 | 38.6
| CHB | 43.8 | 48.2 | 8.0
| CHD | 44.4 | 50.9 | 4.6
| GIH | 35.6 | 50.5 | 13.9
| LWK | 1.9 | 30.6 | 67.6
| MEX | 41.4 | 48.3 | 10.3
| MKK | 6.5 | 38.7 | 54.8
| TSI | 45.1 | 42.2 | 12.7
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20023658
|Trait=Nonsyndromic cleft lip with or without cleft palate
|Title=Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate
|RiskAllele=C
|Pval=1E-8
|OR=1.38
|ORtxt=[1.21-1.56]
}}

{{PMID Auto
|PMID=22021054
|Title=Polymorphic variants at 10q25.3 and 17q22 loci and the risk of non-syndromic cleft lip and palate in the Polish population.
}}

Associated with European Facial [[Appearance]] {{doi|10.1371/journal.pgen.1002932}}
*[[rs7590268]]
*[[rs16903544]]
*[[rs987525]]
*[[rs9574565]]
*[[rs227731]]
*[[rs642961]] 
*[[rs1258763]]

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs227731
|overall_frequency_n=80
|overall_frequency_d=128
|overall_frequency=0.625
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=75
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=22863734
  |Trait=Orofacial clefts
  |Title=Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
  |RiskAllele=C
  |Pval=2E-8
  |OR=1.23
  |ORtxt=[1.078-1.400]
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}