{{Rsnum
|rsid=2278293
|Gene=IMPDH1
|Chromosome=7
|position=128400698
|Orientation=minus
|GMAF=0.4444
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IMPDH1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 14.3 | 60.3 | 25.4
| HCB | 20.0 | 51.1 | 28.9
| JPT | 15.9 | 52.3 | 31.8
| YRI | 24.2 | 51.6 | 24.2
| ASW | 0.0 | 0.0 | 0.0
| CHB | 20.0 | 51.1 | 28.9
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2278293
|Name_s=IMPDH1:IVS7+125G4A
|Gene_s=IMPDH1
|Feature=Intron
|Evidence=PubMed ID:17851563
|Annotation=SNP is significantly associated with the incidence of biopsyproven acute rejection in the first year post-transplantation in kidney transplant patients.
|Drugs=mycophenolate mofetil
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161612544
}}

{{PMID Auto
|PMID=20679962
|Title=Polymorphisms in type I and II inosine monophosphate dehydrogenase genes and association with clinical outcome in patients on mycophenolate mofetil
|OA=1
}}

{{PMID Auto
|PMID=20649757
|Title=Inosine 5'-monophosphate dehydrogenase 1 haplotypes and association with mycophenolate mofetil gastrointestinal intolerance in pediatric heart transplant patients
|OA=1
}}

{{PMID Auto
|PMID=16384941
|Title=Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis.
|OA=1
}}

{{PMID Auto
|PMID=20061166
|Title=Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients.
}}

{{PMID Auto
|PMID=20136638
|Title=Correlation of IMPDH1 gene polymorphisms with subclinical acute rejection and mycophenolic acid exposure parameters on day 28 after renal transplantation.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2278293
|overall_frequency_n=59
|overall_frequency_d=128
|overall_frequency=0.460938
|n_genomes=39
|n_genomes_annotated=0
|n_haplomes=50
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22960765
|Title=Inosine monophosphate dehydrogenase polymorphisms and renal allograft outcome.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}