{{Rsnum
|rsid=2278294
|Gene=IMPDH1
|Chromosome=7
|position=128400645
|Orientation=minus
|GMAF=0.3999
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IMPDH1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 10.6 | 43.4 | 46.0
| HCB | 30.7 | 44.5 | 24.8
| JPT | 23.9 | 46.0 | 30.1
| YRI | 19.0 | 48.3 | 32.7
| ASW | 12.3 | 50.9 | 36.8
| CHB | 30.7 | 44.5 | 24.8
| CHD | 33.9 | 45.0 | 21.1
| GIH | 9.9 | 47.5 | 42.6
| LWK | 4.5 | 47.3 | 48.2
| MEX | 17.9 | 48.2 | 33.9
| MKK | 3.9 | 38.7 | 57.4
| TSI | 12.7 | 43.1 | 44.1
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs2278294
|Name_s=IMPDH1:IVS8-106G4A
|Gene_s=IMPDH1
|Feature=Intron
|Evidence=PubMed ID:17851563
|Annotation=SNP is significantly associated with the incidence of biopsyproven acute rejection in the first year post-transplantation in kidney transplant patients.
|Drugs=mycophenolate mofetil
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA161612545
}}

{{PMID Auto
|PMID=20679962
|Title=Polymorphisms in type I and II inosine monophosphate dehydrogenase genes and association with clinical outcome in patients on mycophenolate mofetil
|OA=1
}}

{{PMID Auto
|PMID=20649757
|Title=Inosine 5'-monophosphate dehydrogenase 1 haplotypes and association with mycophenolate mofetil gastrointestinal intolerance in pediatric heart transplant patients
|OA=1
}}

{{PMID Auto
|PMID=16384941
|Title=Spectrum and frequency of mutations in IMPDH1 associated with autosomal dominant retinitis pigmentosa and leber congenital amaurosis.
|OA=1
}}

{{PMID Auto
|PMID=20061166
|Title=Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients.
}}

{{PMID Auto
|PMID=20136638
|Title=Correlation of IMPDH1 gene polymorphisms with subclinical acute rejection and mycophenolic acid exposure parameters on day 28 after renal transplantation.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2278294
|overall_frequency_n=51
|overall_frequency_d=128
|overall_frequency=0.398438
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=41
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22960765
|Title=Inosine monophosphate dehydrogenase polymorphisms and renal allograft outcome.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}