{{Rsnum
|rsid=2280090
|Gene=ADAM33
|Chromosome=20
|position=3669558
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.146
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=ADAM33
}}[[rs2280090]], a SNP in the [[ADAM33]] gene, has been linked to a predisposition to [[asthma]] and bronchial hyperresponsiveness. [PMID 12110844, PMID 14564349]

{{ neighbor
| rsid = 2280089
| distance = 78
}}
{{PMID Auto
|PMID=19236319
|Title=Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness
}}

{{PMID Auto
|PMID=16519819
|Title=Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
|OA=1
}}

{{PMID Auto
|PMID=16784537
|Title=The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations.
|OA=1
}}

{{PMID Auto
|PMID=17878941
|Title=ADAM33, a new candidate for psoriasis susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=18778489
|Title=Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population.
|OA=1
}}

{{PMID Auto
|PMID=19146844
|Title=ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children.
}}

{{GET Evidence
|gene=ADAM33
|aa_change=Pro774Ser
|aa_change_short=P774S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2280090
|overall_frequency_n=1415
|overall_frequency_d=10736
|overall_frequency=0.1318
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=17
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.025
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=22583515
|Title=ADAM33 polymorphisms, smoking and asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health Study.
}}

{{PMID Auto
|PMID=22851202
|Title=Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians.
}}

{{PMID Auto
|PMID=22871616
|Title=T1 and T2 ADAM33 single nucleotide polymorphisms and the risk of childhood asthma in a Saudi Arabian population: a pilot study.
}}

{{PMID Auto
|PMID=23380143
|Title=A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: a meta-analysis.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}