{{Rsnum
|rsid=2282679
|Gene=GC
|Chromosome=4
|position=71742666
|Orientation=minus
|GMAF=0.2181
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=Less likely to suffer from vitamin D insufficiency
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=GC
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 52.2 | 43.4 | 4.4
| HCB | 46.7 | 43.7 | 9.6
| JPT | 55.8 | 38.9 | 5.3
| YRI | 91.8 | 8.2 | 0.0
| ASW | 80.7 | 19.3 | 0.0
| CHB | 46.7 | 43.7 | 9.6
| CHD | 52.8 | 37.0 | 10.2
| GIH | 46.5 | 46.5 | 6.9
| LWK | 90.0 | 10.0 | 0.0
| MEX | 48.3 | 51.7 | 0.0
| MKK | 91.0 | 8.3 | 0.6
| TSI | 54.9 | 39.2 | 5.9
| HapMapRevision=28
}}

[[rs2282679]], located in the group-specific component (vitamin D binding protein) [[GC]] gene on chromosome 4p12, has been linked by several studies to vitamin D serum concentrations.

In both studies, the allele associated with lower vitamin D, and thus the potential for [[vitamin D insufficiency]], is [[rs2282679]](C). Carriers of two such alleles have lower vitamin D than carriers of one allele, who in turn on average have lower vitamin D levels than [[rs2282679]](A;A) individuals.{{doi|10.1016/S0140-6736(10)60588-0}}

A near-perfect proxy (i.e. substitute) for [[rs2282679]] is reported to be [[rs4588]].

{{PMID Auto GWAS
|PMID=20418485
|Trait=Vitamin D levels
|Title=Genome-wide association study of circulating vitamin D levels
|RiskAllele=C
|Pval=2E-49
|OR=0.38
|ORtxt=[0.32-0.44] unit decrease
|OA=1
}}

{{PMID Auto GWAS
|PMID=20541252
|Trait=Vitamin D insufficiency
|Title=Common genetic determinants of vitamin D insufficiency: a genome-wide association study.
|RiskAllele=
|Pval=2E-109
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=19255064
|Title=Vitamin D-related genes, serum vitamin D concentrations and prostate cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=21972121
|Title=Associations between common variants in GC and DHCR7/NADSYN1 and vitamin D concentration in Chinese Hans.
}}

{{PMID Auto
|PMID=22613962
|Title=Genetic Influences on Vitamin D Status and Forearm Fracture Risk in African American Children.
|OA=1
}}

{{PMID Auto GWAS
|PMID=22673963
|Trait=None
|Title=Genome-wide association analysis of circulating vitamin D levels in children with asthma.
|RiskAllele=
|Pval=2E-14
|OR=None
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22704802
|Title=Vitamin D-binding protein (group-specific component) has decreased expression in rheumatoid arthritis
}}

{{PMID Auto
|PMID=22701574
|Title=Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysis
|OA=1
}}

{{PMID Auto
|PMID=23505139
|Title=An analysis of the association between the vitamin D pathway and serum 25-hydroxyvitamin D levels in a healthy Chinese population
}}

{{PMID Auto
|PMID=23734184
|Title=Genetic Analyses Reveal a Role for Vitamin D Insufficiency in HCV-Associated Hepatocellular Carcinoma Development
|OA=1
}}

{{PMID Auto
|PMID=23924835
|Title=Genetic variant in vitamin D binding protein is associated with serum 25-hydroxyvitamin D and vitamin D insufficiency in southern Chinese
}}

{{PMID Auto
|PMID=24007655
|Title=Genetic variants in Vitamin D pathway in Egyptian asthmatic children: a pilot study
}}

{{PMID Auto
|PMID=23456391
|Title=Serum vitamin D metabolites in colorectal cancer patients receiving cholecalciferol supplementation: correlation with polymorphisms in the vitamin D genes
|OA=1
}}

{{PMID Auto
|PMID=23191998
|Title=Genetic variations in the vitamin D binding protein and season-specific levels of vitamin D among older adults.
}}

{{PMID Auto
|PMID=23319826
|Title=Vitamin D and mortality: a Mendelian randomization study.
}}

{{PMID Auto
|PMID=23468552
|Title=Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults.
|OA=1
}}

{{PMID Auto
|PMID=23793229
|Title=Association of common gene variants in vitamin D modulating genes and colon cancer recurrence.
}}

{{PMID Auto
|PMID=25032819
|Title=Vitamin D time profile based on the contribution of non-genetic and genetic factors in HIV-infected individuals of European ancestry
}}

{{PMID Auto
|PMID=25174667
|Title=Environmental and Genetic Determinants of Vitamin D Insufficiency in 12-month-old Infants
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}