{{Rsnum
|rsid=2284063
|Gene=PLA2G6
|Chromosome=22
|position=38148291
|Orientation=plus
|GMAF=0.3678
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=PLA2G6
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 46.0 | 44.2 | 9.7
| HCB | 54.0 | 38.0 | 8.0
| JPT | 58.4 | 31.9 | 9.7
| YRI | 19.0 | 55.8 | 25.2
| ASW | 49.1 | 29.8 | 21.1
| CHB | 54.0 | 38.0 | 8.0
| CHD | 60.6 | 32.1 | 7.3
| GIH | 19.8 | 58.4 | 21.8
| LWK | 16.4 | 53.6 | 30.0
| MEX | 31.0 | 46.6 | 22.4
| MKK | 18.7 | 50.3 | 31.0
| TSI | 37.3 | 49.0 | 13.7
| HapMapRevision=28
}}[http://blog.23andme.com/2009/07/06/snpwatch-genetic-variants-near-tumor-suppressor-genes-may-increase-risk-for-brain-and-skin-cancer/ 23andMe blog] [[rs2284063]] A 1.20 [[Melanoma]]

{{PMID Auto GWAS
|PMID=19578364
|Trait=Melanoma
|Title=Genome-wide association study identifies three loci associated with melanoma risk
|RiskAllele=
|Pval=2E-9
|OR=1.20
|ORtxt=[1.14-1.28]
|OA=1
}}
{{PMID Auto GWAS
|PMID=19578365
|Trait=Cutaneous nevi
|Title=Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi
|RiskAllele=G
|Pval=3E-8
|OR=0.08
|ORtxt=[-0.002-0.16] decrease in log nevus count
|OA=1
}}

{{omim
|id=155601
|rsnum=2284063
}}

{{omim
|id=162900
|rsnum=2284063
}}

{{PMID Auto
|PMID=19686382
|Title=Genome-wide associations studies for melanoma and nevi.
|OA=1
}}

{{PMID Auto
|PMID=22459563
|Title=Association between PLA2G6 gene polymorphisms and Parkinson's disease in the Chinese Han population.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs2284063
|overall_frequency_n=58
|overall_frequency_d=128
|overall_frequency=0.453125
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=46
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}